Research output per year
Research output per year
- 40 results
Search results
-
2024
Myeloid differentiation factor-2/LY96, a potential predictive biomarker of metastasis and poor outcomes in prostate cancer: clinical implications as a potential therapeutic target
Ferrari, M. G., Jimenez-Uribe, A. P., Wang, L., Hoeppner, L. H., Murugan, P., Hahm, E., Yu, J., Kuzel, T. M., Gradilone, S. A. & Mansini, A. P., Feb 9 2024, In: Oncogene. 43, 7, p. 484-494 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2023
Criteria for preclinical models of cholangiocarcinoma: scientific and medical relevance
CCA Model Consortium, Jul 2023, In: Nature Reviews Gastroenterology and Hepatology. 20, 7, p. 462-480 19 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
The NAMPT Inhibitor FK866 in Combination with Cisplatin Reduces Cholangiocarcinoma Cells Growth
Pant, K., Richard, S., Peixoto, E., Yin, J., Seelig, D. M., Carotenuto, P., Salati, M., Franco, B., Roberts, L. R. & Gradilone, S. A., Mar 2023, In: Cells. 12, 5, 775.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2022
Inhibition of triple‑negative breast cancer proliferation and motility by reactivating p53 and inhibiting overactivated Akt
Cao, W., Shen, R., Richard, S., Liu, Y., Jalalirad, M., Cleary, M. P., D'Assoro, A. B., Gradilone, S. A. & Yang, D. Q., Feb 2022, In: Oncology Reports. 47, 2, 41.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Short-Chain Fatty Acid Butyrate Induces Cilia Formation and Potentiates the Effects of HDAC6 Inhibitors in Cholangiocarcinoma Cells
Pant, K., Richard, S. & Gradilone, S. A., Jan 13 2022, In: Frontiers in Cell and Developmental Biology. 9, 809382.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2021
Histone Deacetylase Sirtuin 1 Promotes Loss of Primary Cilia in Cholangiocarcinoma
Pant, K., Peixoto, E., Richard, S., Biswas, A., O’Sullivan, M. G., Giama, N., Ha, Y., Yin, J., Carotenuto, P., Salati, M., Ren, Y., Yang, R., Franco, B., Roberts, L. R. & Gradilone, S. A., Dec 2021, In: Hepatology. 74, 6, p. 3235-3248 14 p.Research output: Contribution to journal › Article › peer-review
10 Scopus citations -
Synthetic Conjugates of Ursodeoxycholic Acid Inhibit Cystogenesis in Experimental Models of Polycystic Liver Disease
Caballero-Camino, F. J., Rivilla, I., Herraez, E., Briz, O., Santos-Laso, A., Izquierdo-Sanchez, L., Lee-Law, P. Y., Rodrigues, P. M., Munoz-Garrido, P., Jin, S., Peixoto, E., Richard, S., Gradilone, S. A., Perugorria, M. J., Esteller, M., Bujanda, L., Marin, J. J. G., Banales, J. M. & Cossío, F. P., Jan 2021, In: Hepatology. 73, 1, p. 186-203 18 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2020
HDAC6-dependent ciliophagy is involved in ciliary loss and cholangiocarcinoma growth in human cells and murine models
Peixoto, E., Jin, S., Thelen, K., Biswas, A., Richard, S., Morleo, M., Mansini, A., Holtorf, S., Carbone, F., Pastore, N., Ballabio, A., Franco, B. & Gradilone, S. A., Jun 2020, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 318, 6, p. G1022-G1033Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
2019
Characterization of Novel Murine and Human PDAC Cell Models: Identifying the Role of Intestine Specific Homeobox Gene ISX in Hypoxia and Disease Progression
Ganaie, A. A., Parray, A., Hussain, T., Shabaneh, A., Jamroze, A., Ferrari, M. G., Wang, L., Liao, D. J., Koocheckpour, S., Nanda, S., Wang, J., Deng, Y., Gradilone, S., Hinchcliffe, E. H., Konety, B. R. & Bhat, M. S., Aug 2019, In: Translational Oncology. 12, 8, p. 1056-1071 16 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
The Chemosensory Function of Primary Cilia Regulates Cholangiocyte Migration, Invasion, and Tumor Growth
Mansini, A. P., Peixoto, E., Jin, S., Richard, S. & Gradilone, S., Apr 2019, In: Hepatology. 69, 4, p. 1582-1598 17 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Scopus citations -
2018
Combination of a Histone Deacetylase 6 Inhibitor and a Somatostatin Receptor Agonist Synergistically Reduces Hepatorenal Cystogenesis in an Animal Model of Polycystic Liver Disease
Lorenzo Pisarello, M., Masyuk, T. V., Gradilone, S. A., Masyuk, A. I., Ding, J. F., Lee, P. Y. & LaRusso, N. F., Apr 2018, In: American Journal of Pathology. 188, 4, p. 981-994 14 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
MicroRNA (miR)-433 and miR-22 dysregulations induce histone-deacetylase-6 overexpression and ciliary loss in cholangiocarcinoma
Mansini, A. P., Lorenzo Pisarello, M. J., Thelen, K. M., Cruz-Reyes, M., Peixoto, E., Jin, S., Howard, B. N., Trussoni, C. E., Gajdos, G. B., LaRusso, N. F., Perugorria, M. J., Banales, J. M. & Gradilone, S. A., Aug 2018, In: Hepatology. 68, 2, p. 561-573 13 p.Research output: Contribution to journal › Article › peer-review
Open Access52 Scopus citations -
2017
SOX17 regulates cholangiocyte differentiation and acts as a tumor suppressor in cholangiocarcinoma
Merino-Azpitarte, M., Lozano, E., Perugorria, M. J., Esparza-Baquer, A., Erice, O., Santos-Laso, Á., O'Rourke, C. J., Andersen, J. B., Jiménez-Agüero, R., Lacasta, A., D'Amato, M., Briz, Ó., Jalan-Sakrikar, N., Huebert, R. C., Thelen, K. M., Gradilone, S. A., Aransay, A. M., Lavín, J. L., Fernández-Barrena, M. G., Matheu, A., & 5 others, Jul 2017, In: Journal of Hepatology. 67, 1, p. 72-83 12 p.Research output: Contribution to journal › Article › peer-review
Open Access77 Scopus citations -
2015
MicroRNAs and benign biliary tract diseases
Gradilone, S. A., O'Hara, S. P., Masyuk, T. V., Pisarello, M. J. L. & Larusso, N. F., Feb 1 2015, In: Seminars in Liver Disease. 35, 1, p. 26-35 10 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Scopus citations -
2014
Calcium signaling in cilia and ciliary-mediated intracellular calcium signaling: Are they independent or coordinated molecular events?
Masyuk, A. I., Gradilone, S. A. & Larusso, N. F., Nov 1 2014, In: Hepatology. 60, 5, p. 1783-1785 3 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Centrosomal abnormalities characterize human and rodent cystic cholangiocytes and are associated with Cdc25A overexpression
Masyuk, T. V., Lee, S. O., Radtke, B. N., Stroope, A. J., Huang, B., Banales, J. M., Masyuk, A. I., Splinter, P. L., Gradilone, S. A., Gajdos, G. B. & Larusso, N. F., Jan 2014, In: American Journal of Pathology. 184, 1, p. 110-121 12 p.Research output: Contribution to journal › Article › peer-review
20 Scopus citations -
HDAC6 is overexpressed in cystic cholangiocytes and its inhibition reduces cystogenesis
Gradilone, S. A., Habringer, S., Masyuk, T. V., Howard, B. N., Masyuk, A. I. & Larusso, N. F., Mar 2014, In: American Journal of Pathology. 184, 3, p. 600-608 9 p.Research output: Contribution to journal › Article › peer-review
38 Scopus citations -
Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma
Razumilava, N., Gradilone, S. A., Smoot, R. L., Mertens, J. C., Bronk, S. F., Sirica, A. E. & Gores, G. J., Mar 2014, In: Journal of Hepatology. 60, 3, p. 599-605 7 p.Research output: Contribution to journal › Article › peer-review
64 Scopus citations -
2013
Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling
Masyuk, A. I., Huang, B. Q., Radtke, B. N., Gajdos, G. B., Splinter, P. L., Masyuk, T. V., Gradilone, S. A. & LaRusso, N. F., 2013, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 304, 11, p. G1013-G1024Research output: Contribution to journal › Article › peer-review
Open Access117 Scopus citations -
HDAC6 inhibition restores ciliary expression and decreases tumor growth
Gradilone, S. A., Radtke, B. N., Bogert, P. S., Huang, B. Q., Gajdos, G. B. & LaRusso, N. F., Apr 1 2013, In: Cancer Research. 73, 7, p. 2259-2270 12 p.Research output: Contribution to journal › Article › peer-review
Open Access156 Scopus citations -
Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver diseases
Masyuk, T. V., Radtke, B. N., Stroope, A. J., Banales, J. M., Gradilone, S. A., Huang, B., Masyuk, A. I., Hogan, M. C., Torres, V. E. & Larusso, N. F., Jul 2013, In: Hepatology. 58, 1, p. 409-421 13 p.Research output: Contribution to journal › Article › peer-review
Open Access93 Scopus citations -
The zebrafish as a model to study polycystic liver disease
Tietz Bogert, P. S., Huang, B. Q., Gradilone, S. A., Masyuk, T. V., Moulder, G. L., Ekker, S. C. & Larusso, N. F., Jun 1 2013, In: Zebrafish. 10, 2, p. 211-217 7 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
2012
Inhibition of Cdc25A suppresses hepato-renal cystogenesis in rodent models of polycystic kidney and liver disease
Masyuk, T. V., Radtke, B. N., Stroope, A. J., Banales, J. M., Masyuk, A. I., Gradilone, S. A., Gajdos, G. B., Chandok, N., Bakeberg, J. L., Ward, C. J., Ritman, E. L., Kiyokawa, H. & Larusso, N. F., Mar 2012, In: Gastroenterology. 142, 3, p. 622-633.e4Research output: Contribution to journal › Article › peer-review
39 Scopus citations -
2010
Activation of Trpv4 Reduces the Hyperproliferative Phenotype of Cystic Cholangiocytes From an Animal Model of ARPKD
Gradilone, S. A., Masyuk, T. V., Huang, B. Q., Banales, J. M., Lehmann, G. L., Radtke, B. N., Stroope, A., Masyuk, A. I., Splinter, P. L. & LaRusso, N. F., Jul 2010, In: Gastroenterology. 139, 1, p. 304-314.e2Research output: Contribution to journal › Article › peer-review
83 Scopus citations -
Biliary exosomes influence cholangiocyte regulatory mechanisms and proliferation through interaction with primary cilia
Masyuk, A. I., Huang, B. Q., Ward, C. J., Gradilone, S. A., Banales, J. M., Masyuk, T. V., Radtke, B., Splinter, P. L. & LaRusso, N. F., Oct 2010, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 299, 4, p. G990-G999Research output: Contribution to journal › Article › peer-review
236 Scopus citations -
2009
Glucagon induces the gene expression of aquaporin-8 but not that of aquaporin-9 water channels in the rat hepatocyte
Soria, L. R., Gradilone, S. A., Larocca, M. C. & Marinelli, R. A., Apr 2009, In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 296, 4, p. R1274-R1281Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
Primers on molecular pathways - Ion channels: Key regulators of pancreatic physiology
Banales, J. M. & Gradilone, S. A., Nov 2009, In: Pancreatology. 9, 5, p. 556-559 4 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD)
Banales, J. M., Masyuk, T. V., Gradilone, S. A., Masyuk, A. I., Medina, J. F. & LaRusso, N. F., 2009, In: Hepatology. 49, 1, p. 160-174 15 p.Research output: Contribution to journal › Article › peer-review
106 Scopus citations -
2008
Cholangiocyte primary cilia are chemosensory organelles that detect biliary nucleotides via P2Y12 purinergic receptors
Masyuk, A. I., Gradilone, S. A., Banales, J. M., Huang, B. Q., Masyuk, T. V., Lee, S. O., Splinter, P. L., Stroope, A. J. & LaRusso, N. F., Oct 2008, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 295, 4, p. G725-G734Research output: Contribution to journal › Article › peer-review
Open Access139 Scopus citations -
Hepatic cystogenesis is associated with abnormal expression and location of ion transporters and water channels in an animal model of autosomal recessive polycystic kidney disease
Banales, J. M., Masyuk, T. V., Bogert, P. S., Huang, B. Q., Gradilone, S. A., Lee, S. O., Stroope, A. J., Masyuk, A. I., Medina, J. F. & LaRusso, N. F., Dec 2008, In: American Journal of Pathology. 173, 6, p. 1637-1646 10 p.Research output: Contribution to journal › Article › peer-review
64 Scopus citations -
LPS induces the TNF-α-mediated downregulation of rat liver aquaporin-8: Role in sepsis-associated cholestasis
Lehmann, G. L., Carreras, F. I., Soria, L. R., Gradilone, S. A. & Marinelli, R. A., Feb 1 2008, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 294, 2, p. G567-G575Research output: Contribution to journal › Article › peer-review
70 Scopus citations -
2007
Cholangiocyte cilia express TRPV4 and detect changes in luminal tonicity inducing bicarbonate secretion
Gradilone, S. A., Masyuk, A. I., Splinter, P. L., Banales, J. M., Huang, B. Q., Tietz, P. S., Masyuk, T. V. & LaRusso, N. F., Nov 27 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 48, p. 19138-19143 6 p.Research output: Contribution to journal › Article › peer-review
170 Scopus citations -
2005
Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line, WIF-B
Gradilone, S. A., Tietz, P. S., Splinter, P. L., Marinelli, R. A. & LaRusso, N. F., Aug 18 2005, In: BMC Physiology. 5Research output: Contribution to journal › Article › peer-review
Open Access34 Scopus citations -
Phosphoinositide 3-kinase is involved in the glucagon-induced translocation of aquaporin-8 to hepatocyte plasma membrane
Gradilone, S. A., Carreras, F. I., Lehmann, G. L. & Marinelli, R. A., Nov 2005, In: Biology of the Cell. 97, 11, p. 831-836 6 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
2004
Aquaporin water channels in central nervous system
Lehmann, G. L., Gradilone, S. A. & Marinelli, R. A., 2004, In: Current neurovascular research. 1, 4, p. 293-303 11 p.Research output: Contribution to journal › Article › peer-review
59 Scopus citations -
2003
Glucagon induces the plasma membrane insertion of functional aquaporin-8 water channels in isolated rat hepatocytes
Gradilone, S. A., García, F., Huebert, R. C., Tietz, P. S., Larocca, M. C., Kierbel, A., Carreras, F. I., LaRusso, N. F. & Marinelli, R. A., Jun 1 2003, In: Hepatology. 37, 6, p. 1435-1441 7 p.Research output: Contribution to journal › Article › peer-review
Open Access84 Scopus citations -
Rat hepatocyte aquaporin-8 water channels are down-regulated in extrahepatic cholestasis
Carreras, F. I., Gradilone, S. A., Mazzone, A., García, F., Huang, B. Q., Ochoa, J. E., Tietz, P. S., LaRusso, N. F., Calamita, G. & Marinelli, R. A., May 1 2003, In: Hepatology. 37, 5, p. 1026-1033 8 p.Research output: Contribution to journal › Article › peer-review
65 Scopus citations -
2002
Hepatocyte membrane water permeability measured by silicone layer filtering centrifugation
Gradilone, S. A., Ochoa, J. E., García, F., Larocca, M. C., Pellegrino, J. M. & Marinelli, R. A., Mar 1 2002, In: Analytical Biochemistry. 302, 1, p. 104-107 4 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
2001
The Water Channel Aquaporin-8 is Mainly Intracellular in Rat Hepatocytes, and its Plasma Membrane Insertion is Stimulated by Cyclic AMP
García, F., Kierbel, A., Larocca, M. C., Gradilone, S. A., Splinter, P., LaRusso, N. F. & Marinelli, R. A., Apr 13 2001, In: Journal of Biological Chemistry. 276, 15, p. 12147-12152 6 p.Research output: Contribution to journal › Article › peer-review
191 Scopus citations -
1998
Detection of highly glycosylated proteins in polyacrylamide gels
Gradilone, S. A., Arranz, S. E. & Cabada, M. O., Aug 1 1998, In: Analytical Biochemistry. 261, 2, p. 224-227 4 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations