Project Details
Description
Project Summary/Abstract
Aging is a risk factor for cardiovascular disease (CVD), and women who experience premature or early
menopause have a 50% greater risk for CVD-related death compared with women who experience
menopause at the typical age. Indeed, CVD increases aggressively after menopause and is the leading cause
of mortality in women in the US. Autonomic and blood pressure (BP) dysregulation, often demonstrated in
postmenopausal women, is associated with CVD. Although literature suggests that estrogen is cardioprotective
for premenopausal women, little is known regarding how the early loss of sex hormones in premature and early
menopause effect BP regulation. This application for a Mentored Research Scientist Development Award
(K01) is designed to advance knowledge important for understanding mechanisms contributing to increased
CVD in aging women and support the career of Dr. Manda L Keller-Ross, DPT, PhD, an Assistant Professor in
the Department of Rehabilitation Medicine, in the Medical School at the University of Minnesota. Dr. Keller-
Ross is the PI of the Cardiovascular Research and Rehabilitation Laboratory, where the proposed research will
take place. The long-term objectives of this proposal are to determine mechanisms that contribute to greater
risk of CVD in premature and early menopausal women. Specifically, Dr. Keller-Ross aims to determine
mechanisms driving autonomic BP regulation in premature and early menopausal women near the age of
menopausal onset (Aim 1). She will then determine mechanisms driving autonomic BP regulation in women
who have lived ≥10 years without functioning ovaries to determine the long-term effects (Aim 2). This proposal
is in line with the mission of the NIA, to understand the nature of the aging process in women and how the loss
of sex hormones contributes to the number one killer in women, CVD. Dr. Keller-Ross has a clinical research
background and seeks mentored training and skill development to enhance her knowledge on biology of aging,
women’s health specific to the cardiovascular system and menopause and advanced techniques to measure
autonomic function. She will accomplish her career development goals through a combination of formal
coursework, mentored skill and technique development for microneurography to measure muscle sympathetic
nerve activity and noninvasive measures of baroreflex function and the empirical research described above.
Dr. Keller-Ross has established an interdisciplinary mentorship team to guide her in these research and
training activities. This committee has senior-level expertise in aging research in females, autonomic regulation
of BP research and biostatistical analysis. They are eminently qualified and fully committed to assisting Dr.
Keller-Ross to further her training, research and career path and achieve her career objectives. With this
training, Dr. Keller-Ross is poised to become a leading scientist in cardiovascular health in aging women,
producing research that is directly translatable to clinical practice devising strategic preventative and
rehabilitative therapies to improve cardiovascular health, specific to aging women.
Status | Active |
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Effective start/end date | 5/1/20 → 4/30/24 |
Funding
- National Institute on Aging: $131,760.00
- National Institute on Aging: $131,760.00
- National Institute on Aging: $131,760.00
- National Institute on Aging: $131,760.00
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