Calmodulin-dependent regulation of cardiac ryanodine receptor

Project Narrative: Heart failure and arrhythmias are major human health issues, afflicting millions of Americans. It has become clear that leak of calcium from the sarcoplasmic reticulum within the cardiac myocyte between normal heart beats contributes importantly to both of these major cardiac problems. Here we will elucidate the structural and functional problem at the molecular level and develop novel therapeutic strategies.