Chemical Probes as Allosteric Modulators of CK2 Alpha Prime Targeting Huntington's Disease

Project: Research project

Project Details

Description

PROJECT NARRATIVE This work targets the inhibition of an enzyme (CK2α’) that is upregulated in the brains of Huntington’s disease (HD) patients, promoting the degradation of protective proteins. This research will provide an excellent foundation for the validation of this target as therapeutically relevant in HD, and allow for the future development of new drugs that halt or reverse the cognitive and motor decline associated with HD.
StatusFinished
Effective start/end date2/15/211/31/23

Funding

  • National Institute of Neurological Disorders and Stroke: $170,417.00
  • National Institute of Neurological Disorders and Stroke: $227,512.00

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