Project Details
Description
Project Summary
With medical progress and growing efforts to empower individuals in making life-impacting choices, older
individuals are thus more engaged in their behavioral and socioeconomic choices than ever before. These
decisions are multifaceted and nuanced, but unfortunately, older adults often make poor socioeconomic
decisions. Progress in medicine has not only led to increased life expectancy but it has also contributed to a rise
in Alzheimer's disease (AD), the most common form of dementia, due to rapid increase in population aging and
the current absence of AD-modifying therapies. Exploiting recent advances in judgement and decision-making
neuroscience, we now propose a three-pronged effort designed to uncover whether and how Aβ-dependent
mechanisms induce changes in circuits underlying various forms of decision-making and we have formed an
investigative multi-PI team uniquely qualified to pursue these questions. Leveraging exciting new results from
our joint group, we will test the central hypothesis that decision-making in AD mice is altered in a multifaceted
economic- and sex-specific manner. In the light of novel findings reported in the preliminary results, we will i) test
the hypothesis that aging impairs decision-making differentially in male and female mice, ii) test the prediction
that decision-making is impaired in mouse models of AD and worsens with aging and iii) test the hypothesis that
genetic, pharmaceutical and optogenetic intervention will improve decision-making in AD mouse models, thereby
providing a preclinical proof-of-principle that decline in decision-making can be ameliorated.
Status | Active |
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Effective start/end date | 3/1/24 → 2/28/25 |
Funding
- National Institute on Aging: $549,999.00
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