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Project Details
Description
Project Summary
The goal of this proposal is to understand how aging and senescent cells impact resident memory T cell
differentiation, longevity, and functional interactions with individual tissue cell types, including parenchymal,
stromal, innate and adaptive immune cells. Single cell assays will address gaps in understanding of resident
memory T cell dialogue with resident hematopoietic and non-hematopoietic cells in both mouse and humans.
The impact of the age of the organism, the age of the T cell, or targeted elimination of senescent cell populations
will be tested as isolated variables. This study will inform mechanisms of immune disfunction in the elderly and
therapeutic opportunities for rejuvenating tissue immunity.
Status | Active |
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Effective start/end date | 1/1/24 → 12/31/24 |
Funding
- National Institute of Allergy and Infectious Diseases: $539,772.00
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Projects
- 1 Active
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The role of senescent cells in dysregulating immune responses and pathogen control
Jameson, S. S. C., Masopust, D., Niedernhofer, L. J., Hamilton Hart, S. E. & Dong, X. X.
3/11/24 → 2/28/25
Project: Research project