EPR OF FERRIC TALLYSMYCIN (TCM) &EFFECT OF OLIGONUCLEOTIDES

  • Que, Larry (PI)
  • Bender, Chris (PI)
  • Lippai, Istvan (PI)
  • Mildvan, Albert S. (PI)
  • Magliozzo, Richard S. (PI)

Project: Research project

Project Details

Description

Continuous wave EPR spectroscopy is being used to characterize the iron-binding domain of a synthetic model (PMA) of the antitumor antibiotic, bleomycin. The EPR spectra of two very similar low-spin ferric complexes have been differentiated and assigned as a methoxide and hydroperoxide form of Fe(III) PMA.
StatusFinished
Effective start/end date10/1/89 → 9/30/99

Funding

  • National Center for Research Resources

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  • BIOTECHNOLOGY RESOURCE IN PULSED EPR SPECTROSCOPY

    Mildvan, A. S., Nersissian, A. A., Lee, C. C. C., Stafford, D. D. W., Singel, D. D., Ash, D. D. E., Janson, E. E., Guajardo, G. G. B., Dyson, H. H. J., Peisach, J. J., Wittaker, J. J., Fee, J. J. A., Kozarich, J. J., Shanklin, J., Chan, J. J., Sam, J. J., Colaneri, M. M., Walter, P. P., Danzinger, R. R., Banerjee, R., Schramm, V. L., Wang, W. W., Mims, W. W. B., Aisen, P., Armstrong, W. H., Astroff, N., Avdievich, N., Baker, T. A., Bender, C., Benkovic, S. J., Brewer, C. F., Brewer, F., Britt, D., Cammack, R., Caradonna, J. P., Chan, J., Danzinger, R., Das, T., Dooley, D., Ettinger, M., Fabry, M. E., Fee, J. A., Frank, N. H. A., Friedman, J. M., Gerfen, G. J., Goutermann, M., Kamp, N., Lee, C. C., Lippai, I., Magliozzo, R. S., Mason, R., McMillin, D. R., Michael, D., Mims, W. B., Narasimhulu, S., Ohnishi, T., Palmer, G., Que, L., Rousseau, D. L., Scholes, C. P., Shaka, O., Sinclair, P., Stegeman, J. J., Stubbe, N. J. A., Stubbe, J., Tipton, P., Villafranca, N. J. J., Wang, W., Zweier, J., Belford, L., Beltramini, M., Chance, M., Clarkson, R., Coffino, A., Crowder, M. W., Ranney, H. H., Klinman, J. J., Klein, M., Krzystek, Y., Licht, S., Marcinkeviciene, J., Gluck, M. M. R., Mcdermott, A., Bowman, M. K., Ming, L. J., Sumuni, R. R., Sands, R. H., Sheik, A., Stubbe, J., Tsuneshige, A., Valentine, J., Vieso, V., Wirt, M., Wong, K. & Zhang, C.

    9/30/85 → 4/30/00

    Project: Research project