Evaluation of CRAG screening with enhanced antifungal therapy for asymptomatic CRAG-positive persons

Cryptococcal meningitis is a leading cause of AIDS-related deaths worldwide and can be prevented by screening for cryptococcal antigen (CRAG) in the blood before onset of meningitis symptoms. CRAG screening and preemptive treatment per WHO recommendations improves survival, though 30% of CRAG+ persons still die despite preemptive treatment. The objective of this study is to identify a more clinically effective treatment strategy for asymptomatic CRAG+ persons that is also cost-effective.