Projects per year
Project Details
Description
Summary
This application requests continued support for a long-standing P01 project on peripheral tolerance. This has
been a highly productive P01 that provided mechanistic insight about clonal deletion and anergy. These
discoveries were made through technical innovation in how to identify and manipulate self-antigen specific T
cells using pMHC tetramers. Based on preliminary data suggesting that mice with normal microbial experience
have strikingly altered immunity compared to specific pathogen free mice, we propose to focus in the next
period on understanding tolerance in the face of diverse pathogen experience, which is the reality for wild
animals and humans. The program includes five projects that will focus on distinct but complimentary aspects
of tolerance: natural MHCII-bound self epitope discovery, polyclonal anergic cells, type I interferons, non-
deletional CD8+ T cell tolerance, and hybrid self-peptides. The five investigatorial teams propose a strongly
synergistic plan to build a comprehensive understanding of physiologic T cell tolerance mechanisms that
operate in the face of normal microbial experience, and to continue to develop tools that have a broad impact
as we do so. The project includes three core facilities to enhance research productivity: 1) a mouse core to
facilitate and standardize research on mice bearing a diverse pathogen load, 2) a human tissue core to
facilitate the immunological analysis of multiple human tissues, not merely peripheral blood, and 3) an
administrative core to carry out activities that enhance the synergy and productivity of the group.
Status | Active |
---|---|
Effective start/end date | 9/30/93 → 8/31/24 |
Funding
- National Institute of Allergy and Infectious Diseases: $1,729,938.00
- National Institute of Allergy and Infectious Diseases: $758,631.00
- National Institute of Allergy and Infectious Diseases: $568,122.00
- National Institute of Allergy and Infectious Diseases: $601,682.00
- National Institute of Allergy and Infectious Diseases: $33,033.00
- National Institute of Allergy and Infectious Diseases: $492,524.00
- National Institute of Allergy and Infectious Diseases: $1,689,694.00
- National Institute of Allergy and Infectious Diseases: $2,123,951.00
- National Institute of Allergy and Infectious Diseases: $686,631.00
- National Institute of Allergy and Infectious Diseases: $1,689,418.00
- National Institute of Allergy and Infectious Diseases: $2,173,652.00
- National Institute of Allergy and Infectious Diseases: $2,182,594.00
- National Institute of Allergy and Infectious Diseases: $1,679,927.00
- National Institute of Allergy and Infectious Diseases: $63,027.00
- National Institute of Allergy and Infectious Diseases: $2,153,562.00
- National Institute of Allergy and Infectious Diseases: $776,505.00
- National Institute of Allergy and Infectious Diseases: $2,093,746.00
- National Institute of Allergy and Infectious Diseases: $741,294.00
- National Institute of Allergy and Infectious Diseases: $776,236.00
- National Institute of Allergy and Infectious Diseases: $1,359,583.00
- National Institute of Allergy and Infectious Diseases: $1,679,927.00
- National Institute of Allergy and Infectious Diseases: $1,378,767.00
- National Institute of Allergy and Infectious Diseases: $1,470,840.00
- National Institute of Allergy and Infectious Diseases: $1,352,783.00
- National Institute of Allergy and Infectious Diseases: $14,496.00
- National Institute of Allergy and Infectious Diseases: $1,314,073.00
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.
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Type I interferons in tolerance in the steady state
Hogquist, K. K. A.
National Institute of Allergy and Infectious Diseases
9/1/23 → 8/31/24
Project: Research project
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Admin Core
Hogquist, K. K. A.
National Institute of Allergy and Infectious Diseases
9/1/23 → 8/31/24
Project: Research project
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Type I interferons in tolerance in the steady state
Hogquist, K. A. & Hogquist, K. K. A.
National Institute of Allergy and Infectious Diseases
7/25/19 → 8/31/23
Project: Research project