Perilipin 5: Linking lipid droplets to nutrient sensing and healthy aging

NARRATIVE The goal of this application is to dissect out the unique functions of Perilipin5 and its role in healthspan and longevity-inducing interventions. This work is a significant as Perilipin5 has been shown to mitigate metabolic disease but its ability to influence health or lifespan has yet to be established. By focusing on a novel niche in lipid signaling and directly relating Perilipin5 to health and lifespan, we are establishing strong fundamental biology that is extremely relevant to healthy aging and healthspan promoting interventions.