Personalized Statin Treatment Plan to Optimize Clinical Outcomes Using Big Data

PROJECT NARRATIVE About 50% of patients prescribed statins do not obtain critical benefits in lowering low-density lipoprotein cholesterol, preventing atherosclerotic cardiovascular disease, and reducing all-cause mortality because they discontinue use within 1 year of treatment initiation largely due to statin-associated symptoms. Statin discontinuation has been identified as a major public-health concern due to increased morbidity, mortality, and healthcare costs associated with atherosclerotic cardiovascular disease. The proposed study will produce a personalized (“precision”)-medicine tool using big data to empower physicians to make proactive clinical decisions for prescribing statins that will maximize LDL reduction and minimize statin discontinuation and statin-associated symptoms.