Roles of Iron-Dependent PHD and JARID in Early-Life Iron Deficiency-Induced Adult Neural Gene Dysregulation

PUBLIC HEALTH RELEVANCE We investigate the roles of iron-dependent cellular mechanisms in developing brain by which early-life iron de- ficiency, the most common micronutrient deficiency worldwide, causes persistent cognitive and socio- emotional behavior deficits in adulthood. Our studies would lead to changes in when infants are screened and when treatment should begin for iron deficiency, and to the discovery of adjunct treatments to reduce long-term neurologic problems.