1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model

Masafumi Ono; Shigetaka Kageyama; Neil O'Leary; Mohammed S. El-Kurdi; Jochen Reinöhl; Eric Solien; Richard W. Bianco; Mirko Doss; Bart Meuris; Renu Virmani; Martijn Cox; Yoshinobu Onuma; Patrick W. Serruys

doi:10.1016/j.jacbts.2022.06.021

1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model

Masafumi Ono, Shigetaka Kageyama, Neil O'Leary, Mohammed S. El-Kurdi, Jochen Reinöhl, Eric Solien, Richard W. Bianco, Mirko Doss, Bart Meuris, Renu Virmani, Martijn Cox, Yoshinobu Onuma, Patrick W. Serruys

Surgery

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Many attempts have been made to inhibit or counteract saphenous vein graft (SVG) failure modes; however, only external support for SVGs has gained momentum in clinical utility. This study revealed the feasibility of implantation, and showed good patency out to 12 months of the novel biorestorative graft, in a challenging ovine coronary artery bypass graft model. This finding could trigger the first-in-man trial of using the novel material instead of SVG. We believe that, eventually, this novel biorestorative bypass graft can be one of the options for coronary artery bypass graft patients who have difficulty harvesting SVG.

Original language	English (US)
Pages (from-to)	19-34
Number of pages	16
Journal	JACC: Basic to Translational Science
Volume	8
Issue number	1
DOIs	https://doi.org/10.1016/j.jacbts.2022.06.021
State	Published - Jan 2023

Bibliographical note

Funding Information:
The authors thank the team at American Preclinical Services.

Publisher Copyright:
© 2023 The Authors

Keywords

coronary artery bypass graft
coronary artery disease
coronary revascularization
polymeric bypass graft
preclinical model
quantitative flow ratio
restorative vascular graft

PubMed: MeSH publication types

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title = "1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model",

abstract = "Many attempts have been made to inhibit or counteract saphenous vein graft (SVG) failure modes; however, only external support for SVGs has gained momentum in clinical utility. This study revealed the feasibility of implantation, and showed good patency out to 12 months of the novel biorestorative graft, in a challenging ovine coronary artery bypass graft model. This finding could trigger the first-in-man trial of using the novel material instead of SVG. We believe that, eventually, this novel biorestorative bypass graft can be one of the options for coronary artery bypass graft patients who have difficulty harvesting SVG.",

keywords = "coronary artery bypass graft, coronary artery disease, coronary revascularization, polymeric bypass graft, preclinical model, quantitative flow ratio, restorative vascular graft",

author = "Masafumi Ono and Shigetaka Kageyama and Neil O'Leary and El-Kurdi, {Mohammed S.} and Jochen Rein{\"o}hl and Eric Solien and Bianco, {Richard W.} and Mirko Doss and Bart Meuris and Renu Virmani and Martijn Cox and Yoshinobu Onuma and Serruys, {Patrick W.}",

note = "Funding Information: The authors thank the team at American Preclinical Services. Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

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doi = "10.1016/j.jacbts.2022.06.021",

language = "English (US)",

volume = "8",

pages = "19--34",

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T1 - 1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model

AU - Ono, Masafumi

AU - Kageyama, Shigetaka

AU - O'Leary, Neil

AU - El-Kurdi, Mohammed S.

AU - Reinöhl, Jochen

AU - Solien, Eric

AU - Bianco, Richard W.

AU - Doss, Mirko

AU - Meuris, Bart

AU - Virmani, Renu

AU - Cox, Martijn

AU - Onuma, Yoshinobu

AU - Serruys, Patrick W.

PY - 2023/1

Y1 - 2023/1

N2 - Many attempts have been made to inhibit or counteract saphenous vein graft (SVG) failure modes; however, only external support for SVGs has gained momentum in clinical utility. This study revealed the feasibility of implantation, and showed good patency out to 12 months of the novel biorestorative graft, in a challenging ovine coronary artery bypass graft model. This finding could trigger the first-in-man trial of using the novel material instead of SVG. We believe that, eventually, this novel biorestorative bypass graft can be one of the options for coronary artery bypass graft patients who have difficulty harvesting SVG.

AB - Many attempts have been made to inhibit or counteract saphenous vein graft (SVG) failure modes; however, only external support for SVGs has gained momentum in clinical utility. This study revealed the feasibility of implantation, and showed good patency out to 12 months of the novel biorestorative graft, in a challenging ovine coronary artery bypass graft model. This finding could trigger the first-in-man trial of using the novel material instead of SVG. We believe that, eventually, this novel biorestorative bypass graft can be one of the options for coronary artery bypass graft patients who have difficulty harvesting SVG.

KW - coronary artery bypass graft

KW - coronary artery disease

KW - coronary revascularization

KW - polymeric bypass graft

KW - preclinical model

KW - quantitative flow ratio

KW - restorative vascular graft

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1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Access

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