TY - JOUR
T1 - 1,3-Butadiene exposure and metabolism among Japanese American, Native Hawaiian, and white smokers
AU - Park, Sungshim Lani
AU - Kotapati, Srikanth
AU - Wilkens, Lynne R.
AU - Tiirikainen, Maarit
AU - Murphy, Sharon E.
AU - Tretyakova, Natalia
AU - Le Marchand, Loïc
N1 - Publisher Copyright:
©2014 AACR.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Background: We hypothesize that the differences in lung cancer risk in Native Hawaiians, whites, and Japanese Americans may, in part, be due to variation in the metabolism of 1,3-butadiene, one of the most abundant carcinogens in cigarette smoke. Methods: We measured two biomarkers of 1,3-butadiene exposure, monohydroxybutyl mercapturic acid (MHBMA) and dihydroxybutyl mercapturic acid (DHBMA), in overnight urine samples among 584 Native Hawaiians, Japanese Americans, and white smokers in Hawaii. These values were normalized to creatinine levels. Ethnic-specific geometric means were compared adjusting for age at urine collection, sex, body mass index, and nicotine equivalents (a marker of total nicotine uptake). Results: We found that mean urinary MHBMA differed by race/ethnicity (P = 0.0002). The values were highest in whites and lowest in Japanese Americans. This difference was only observed in individuals with the GSTT1-null genotype (P = 0.0001).Nodifference across race/ethnicity was foundamong those with at least one copy of the GSTT1 gene (P ≥ 0.72). Mean urinary DHBMA did not differ across racial/ethnic groups. Conclusions: The difference in urinaryMHBMAexcretion levels from cigarette smoking across three ethnic groups is, in part, explained by the GSTT1 genotype. Mean urinaryMHBMAlevels are higher in whites among GSTT1-null smokers. Impact: The overall higher excretion levels of MHBMA in whites and lower levels of MHBMA in Japanese Americans are consistent with the higher lung cancer risk in the former. However, the excretion levels of MHBMAin Native Hawaiians are not consistent with their disease risk and thus unlikely to explain their high risk of lung cancer.
AB - Background: We hypothesize that the differences in lung cancer risk in Native Hawaiians, whites, and Japanese Americans may, in part, be due to variation in the metabolism of 1,3-butadiene, one of the most abundant carcinogens in cigarette smoke. Methods: We measured two biomarkers of 1,3-butadiene exposure, monohydroxybutyl mercapturic acid (MHBMA) and dihydroxybutyl mercapturic acid (DHBMA), in overnight urine samples among 584 Native Hawaiians, Japanese Americans, and white smokers in Hawaii. These values were normalized to creatinine levels. Ethnic-specific geometric means were compared adjusting for age at urine collection, sex, body mass index, and nicotine equivalents (a marker of total nicotine uptake). Results: We found that mean urinary MHBMA differed by race/ethnicity (P = 0.0002). The values were highest in whites and lowest in Japanese Americans. This difference was only observed in individuals with the GSTT1-null genotype (P = 0.0001).Nodifference across race/ethnicity was foundamong those with at least one copy of the GSTT1 gene (P ≥ 0.72). Mean urinary DHBMA did not differ across racial/ethnic groups. Conclusions: The difference in urinaryMHBMAexcretion levels from cigarette smoking across three ethnic groups is, in part, explained by the GSTT1 genotype. Mean urinaryMHBMAlevels are higher in whites among GSTT1-null smokers. Impact: The overall higher excretion levels of MHBMA in whites and lower levels of MHBMA in Japanese Americans are consistent with the higher lung cancer risk in the former. However, the excretion levels of MHBMAin Native Hawaiians are not consistent with their disease risk and thus unlikely to explain their high risk of lung cancer.
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U2 - 10.1158/1055-9965.EPI-14-0492
DO - 10.1158/1055-9965.EPI-14-0492
M3 - Article
C2 - 25368399
AN - SCOPUS:84920199157
SN - 1055-9965
VL - 23
SP - 2240
EP - 2249
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 11
ER -