Abstract
Objective: This study was undertaken to determine whether 17-hydroxyprogesterone caproate (17P) has a vasoactive effect on fetoplacental vasculature. Study design: Two cotyledons were obtained from each of 5 placentas. Baseline perfusion was established with Hanks-based solution. One cotyledon from each pair was then infused with perfusate to which U46619 a thromboxane sympathomimetic had been added. After 30 minutes, a dose of 17P was then administered to each cotyledon. Finally, a vasoconstricting dose of angiotensin II was administered to each cotyledon. Perfusion pressures were recorded throughout. Statistical analysis of pressure change for a single cotyledon was performed by using a paired t test. Statistical analysis of mean perfusion pressure difference between U46619 exposed and nonexposed cotyledons was analyzed by using a students t test. Results: 17P did not significantly alter the perfusion pressure of the control cotyledon. (30.6 ± 8.3 mm Hg vs 30.1 ± 7.8 mm Hg P = .48). 17P administration significantly lowered the perfusion pressure of the U46619 preconstricted vessels in comparison with preadministration. (60.1 ± 13 mm Hg vs 27.3 ± 7.1 mm Hg P = .03). Both groups of cotyledons responded with vasoconstriction to angiotension II with no difference in response between groups (38.3 ± 12 mm Hg vs 45.8 ± 8.2 mm Hg P = .63). Conclusion: 17P reverses induced vasoconstriction by U46619 in fetoplacental arteries.
Original language | English (US) |
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Pages (from-to) | 1011-1014 |
Number of pages | 4 |
Journal | American journal of obstetrics and gynecology |
Volume | 195 |
Issue number | 4 |
DOIs | |
State | Published - Oct 2006 |
Bibliographical note
Funding Information:Supported by a research grant provided by the Air Force Institute of Technology.
Keywords
- Placenta
- Placental vessels
- Pregnancy
- Progesterone