Abstract
Dianion imine addition, cyclisation reaction between ethyl-3-hydroxybutyrate and aldimines generates β-lactams with the hydroxyethyl sidechain of thienamycin and related β-lactam antibiotics in place. The effects of the N-arylaldimine and the reaction conditions on the stereochemistry of the resulting products are examined.
Original language | English (US) |
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Pages (from-to) | 3903-3906 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 26 |
Issue number | 33 |
DOIs | |
State | Published - 1985 |
Bibliographical note
Funding Information:a grant from the National Institutes of Health.