Abstract
The trigeminal nerve (Vn) plays a unique role in protecting specialized sense organs of the head and oral cavity, such as the retina, from environmental challenges. Pain is the dominant sensation evoked by stimulation of dental pulp, cornea or dura, tissues supplied by almost exclusively by small diameter afferent fibers and that terminate as free nerve endings. Neuroimmune mechanisms act peripherally and centrally to modify craniofacial pain. Sex hormone status is a key factor in many craniofacial pain conditions which are often more prevalent in females than males.
| Original language | English (US) |
|---|---|
| Title of host publication | The Senses |
| Subtitle of host publication | A Comprehensive Reference: Volume 1-7, Second Edition |
| Publisher | Elsevier |
| Pages | 522-539 |
| Number of pages | 18 |
| Volume | 5 |
| ISBN (Electronic) | 9780128054093 |
| ISBN (Print) | 9780128054086 |
| DOIs | |
| State | Published - Jan 1 2020 |
Bibliographical note
Publisher Copyright:© 2021 Elsevier Inc. All rights reserved.
Keywords
- Cornea
- Craniofacial pain
- Dental pain
- Dura
- Meningeal pain
- Neuroimmune biomarkers
- Ocular pain
- Sex differences
- Tooth pulp
- Trigeminal brainstem
- Trigeminal ganglion
- Trigeminal nociceptors