TY - JOUR
T1 - A bad rap
T2 - Rap1 signaling and oncogenesis
AU - Largaespada, David A.
PY - 2003/7/1
Y1 - 2003/7/1
N2 - In the paper by Ishida et al. in this issue of Cancer Cell, the authors report the results of targeted inactivation of a Rap1-specific GTPase-activating protein (GAP) gene, called SPA-1, in mice. Rap1 hyperactivation was observed in hematopoietic cells, which led over time to features associated with symptoms typical of human myeloid dyslastic and myeloid proliferative diseases. The authors present additional data showing that the level of Rap1 activation is important for regulating myelopoiesis and that, in the right context, can deliver an oncogenic signal.
AB - In the paper by Ishida et al. in this issue of Cancer Cell, the authors report the results of targeted inactivation of a Rap1-specific GTPase-activating protein (GAP) gene, called SPA-1, in mice. Rap1 hyperactivation was observed in hematopoietic cells, which led over time to features associated with symptoms typical of human myeloid dyslastic and myeloid proliferative diseases. The authors present additional data showing that the level of Rap1 activation is important for regulating myelopoiesis and that, in the right context, can deliver an oncogenic signal.
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U2 - 10.1016/S1535-6108(03)00171-5
DO - 10.1016/S1535-6108(03)00171-5
M3 - Review article
C2 - 12892706
AN - SCOPUS:0042850282
SN - 1535-6108
VL - 4
SP - 3
EP - 4
JO - Cancer Cell
JF - Cancer Cell
IS - 1
ER -
