A malignant cutaneous neuroendocrine tumor with features of merkel cell carcinoma and differentiating neuroblastoma

Vijay Vanchinathan; Elena C. Marinelli; Reena V. Kartha; Alison Uzieblo; Mahendra Ranchod; Uma N. Sundram

doi:10.1097/DAD.0b013e31819114c4

A malignant cutaneous neuroendocrine tumor with features of merkel cell carcinoma and differentiating neuroblastoma

Vijay Vanchinathan, Elena C. Marinelli, Reena V. Kartha, Alison Uzieblo, Mahendra Ranchod, Uma N. Sundram

Experimental and Clinical Pharmacology

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

We report an unusual primary cutaneous neuroendocrine carcinoma that shows histologic and immunohistochemical features of ganglioneuroblastoma/ differentiating neuroblastoma. The neoplasm is composed predominantly of small atypical neoplastic cells embedded in distinct clusters of immature and mature ganglion cells with associated neuropil. The neoplastic cells show strong perinuclear staining for cytokeratin 20 (CK20) with a dot-like pattern, supporting our contention that this is an unusual variant of Merkel cell carcinoma. To the best of our knowledge, ganglioneuroblastoma-like differentiation has not been previously described in Merkel cell carcinoma.

Original language	English (US)
Pages (from-to)	193-196
Number of pages	4
Journal	American Journal of Dermatopathology
Volume	31
Issue number	2
DOIs	https://doi.org/10.1097/DAD.0b013e31819114c4
State	Published - Apr 1 2009

Keywords

CK20
Cutaneous
Merkel cell carcinoma
Neuroblastoma
Primitive neuroectodermal tumor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1097/DAD.0b013e31819114c4

OpenUrl availability

Full text

Cite this

@article{0bdd08ea2a2d4f218b24864fe2ae9ad2,

title = "A malignant cutaneous neuroendocrine tumor with features of merkel cell carcinoma and differentiating neuroblastoma",

abstract = "We report an unusual primary cutaneous neuroendocrine carcinoma that shows histologic and immunohistochemical features of ganglioneuroblastoma/ differentiating neuroblastoma. The neoplasm is composed predominantly of small atypical neoplastic cells embedded in distinct clusters of immature and mature ganglion cells with associated neuropil. The neoplastic cells show strong perinuclear staining for cytokeratin 20 (CK20) with a dot-like pattern, supporting our contention that this is an unusual variant of Merkel cell carcinoma. To the best of our knowledge, ganglioneuroblastoma-like differentiation has not been previously described in Merkel cell carcinoma.",

keywords = "CK20, Cutaneous, Merkel cell carcinoma, Neuroblastoma, Primitive neuroectodermal tumor",

author = "Vijay Vanchinathan and Marinelli, {Elena C.} and Kartha, {Reena V.} and Alison Uzieblo and Mahendra Ranchod and Sundram, {Uma N.}",

year = "2009",

month = apr,

day = "1",

doi = "10.1097/DAD.0b013e31819114c4",

language = "English (US)",

volume = "31",

pages = "193--196",

journal = "American Journal of Dermatopathology",

issn = "0193-1091",

publisher = "Lippincott Williams and Wilkins",

number = "2",

}

TY - JOUR

T1 - A malignant cutaneous neuroendocrine tumor with features of merkel cell carcinoma and differentiating neuroblastoma

AU - Vanchinathan, Vijay

AU - Marinelli, Elena C.

AU - Kartha, Reena V.

AU - Uzieblo, Alison

AU - Ranchod, Mahendra

AU - Sundram, Uma N.

PY - 2009/4/1

Y1 - 2009/4/1

N2 - We report an unusual primary cutaneous neuroendocrine carcinoma that shows histologic and immunohistochemical features of ganglioneuroblastoma/ differentiating neuroblastoma. The neoplasm is composed predominantly of small atypical neoplastic cells embedded in distinct clusters of immature and mature ganglion cells with associated neuropil. The neoplastic cells show strong perinuclear staining for cytokeratin 20 (CK20) with a dot-like pattern, supporting our contention that this is an unusual variant of Merkel cell carcinoma. To the best of our knowledge, ganglioneuroblastoma-like differentiation has not been previously described in Merkel cell carcinoma.

AB - We report an unusual primary cutaneous neuroendocrine carcinoma that shows histologic and immunohistochemical features of ganglioneuroblastoma/ differentiating neuroblastoma. The neoplasm is composed predominantly of small atypical neoplastic cells embedded in distinct clusters of immature and mature ganglion cells with associated neuropil. The neoplastic cells show strong perinuclear staining for cytokeratin 20 (CK20) with a dot-like pattern, supporting our contention that this is an unusual variant of Merkel cell carcinoma. To the best of our knowledge, ganglioneuroblastoma-like differentiation has not been previously described in Merkel cell carcinoma.

KW - CK20

KW - Cutaneous

KW - Merkel cell carcinoma

KW - Neuroblastoma

KW - Primitive neuroectodermal tumor

UR - http://www.scopus.com/inward/record.url?scp=67649669091&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67649669091&partnerID=8YFLogxK

U2 - 10.1097/DAD.0b013e31819114c4

DO - 10.1097/DAD.0b013e31819114c4

M3 - Article

C2 - 19318809

AN - SCOPUS:67649669091

SN - 0193-1091

VL - 31

SP - 193

EP - 196

JO - American Journal of Dermatopathology

JF - American Journal of Dermatopathology

IS - 2

ER -

A malignant cutaneous neuroendocrine tumor with features of merkel cell carcinoma and differentiating neuroblastoma

Abstract

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this