Abstract
Plasmid‐encoded mercuric reduction involves transfer of Hg2+ across the cellular envelope and reduction to Hg0 by the cytoplasmic mercuric reductase using NADPH. A mathematical model was developed for the binding and transfer of Hg2+ by transport proteins and the subsequent reduction of Hg2+. The values of the model parameters were determined using experimental data. The derived rate expressions were similar to the previously experimentally determined ones. The model predicted that a differential amplification of the transport protein relative to mercuric reductase expression levels may enhance the Hg2+ reduction rate in whole cells.
Original language | English (US) |
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Pages (from-to) | 47-54 |
Number of pages | 8 |
Journal | Biotechnology and bioengineering |
Volume | 37 |
Issue number | 1 |
DOIs | |
State | Published - Jan 5 1991 |