@article{8c76095001b346aaa392766f47808293,
title = "A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation",
abstract = "The mechanisms that protect from febrile malaria remain unclear. Tran et al. applied a systems-based approach to a longitudinal pediatric study to identify immune signatures that associate with control of malaria fever and parasitemia, revealing that p53 upregulation in monocytes attenuates malaria-induced inflammation and predicts protection from fever.",
keywords = "Plasmodium falciparum, RNA sequencing, RNA-seq, antibody profiling, flow cytometry, malaria, malaria immunity, prospective cohort study, systems biology, systems immunology, transcriptomics",
author = "Tran, {Tuan M.} and Rajan Guha and Silvia Portugal and Jeff Skinner and Aissata Ongoiba and Jyoti Bhardwaj and Marcus Jones and Jacqueline Moebius and Pratap Venepally and Safiatou Doumbo and DeRiso, {Elizabeth A.} and Shanping Li and Kamalakannan Vijayan and Anzick, {Sarah L.} and Hart, {Geoffrey T.} and O'Connell, {Elise M.} and Doumbo, {Ogobara K.} and Alexis Kaushansky and Galit Alter and Felgner, {Phillip L.} and Hernan Lorenzi and Kassoum Kayentao and Boubacar Traore and Kirkness, {Ewen F.} and Crompton, {Peter D.}",
note = "Publisher Copyright: {\textcopyright} 2019",
year = "2019",
month = oct,
day = "15",
doi = "10.1016/j.immuni.2019.08.009",
language = "English (US)",
volume = "51",
pages = "750--765.e10",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",
number = "4",
}
