A multicenter study: North american islet donor score in donor pancreas selection for human islet isolation for transplantation

Ling Jia Wang; Tatsuya Kin; Doug O’Gorman; A. M James Shapiro; Bashoo Naziruddin; Morihito Takita; Marlon F. Levy; Andrew M. Posselt; Gregory L. Szot; Omid Savari; Barbara Barbaro; James McGarrigle; Chunchieh Yeh; Jose Oberholzer; Ji Lei; Tao Chen; Moh Lian; James F. Markmann; Alejandro Alvarez; Elina Linetsky; Camillo Ricordi; A. N. Balamurugan; Gopalakrishnan Loganathan; Joshua J. Wilhelm; Bernhard J. Hering; Rita Bottino; Massimo Trucco; Chengyang Liu; Zaw Min; Yanjing Li; Ali Naji; Luis A. Fernandez; Martynas Ziemelis; Juan S. Danobeitia; J. Michael Millis; Piotr Witkowski

doi:10.3727/096368916X691141

A multicenter study: North american islet donor score in donor pancreas selection for human islet isolation for transplantation

Ling Jia Wang, Tatsuya Kin, Doug O’Gorman, A. M James Shapiro, Bashoo Naziruddin, Morihito Takita, Marlon F. Levy, Andrew M. Posselt, Gregory L. Szot, Omid Savari, Barbara Barbaro, James McGarrigle, Chunchieh Yeh, Jose Oberholzer, Ji Lei, Tao Chen, Moh Lian, James F. Markmann, Alejandro Alvarez, Elina LinetskyCamillo Ricordi, A. N. Balamurugan, Gopalakrishnan Loganathan, Joshua J. Wilhelm, Bernhard J. Hering, Rita Bottino, Massimo Trucco, Chengyang Liu, Zaw Min, Yanjing Li, Ali Naji, Luis A. Fernandez, Martynas Ziemelis, Juan S. Danobeitia, J. Michael Millis, Piotr Witkowski

Surgery

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Abstract

Selection of an optimal donor pancreas is the first key task for successful islet isolation. We conducted a retrospective multicenter study in 11 centers in North America to develop an islet donor scoring system using donor variables. The data set consisting of 1,056 deceased donors was used for development of a scoring system to predict islet isolation success (defined as postpurification islet yield >400,000 islet equivalents). With the aid of univariate logistic regression analyses, we developed the North American Islet Donor Score (NAIDS) ranging from 0 to 100 points. The c index in the development cohort was 0.73 (95% confidence interval 0.70–0.76). The success rate increased proportionally as the NAIDS increased, from 6.8% success in the NAIDS < 50 points to 53.7% success in the NAIDS ≥ 80 points. We further validated the NAIDS using a separate set of data consisting of 179 islet isolations. A comparable outcome of the NAIDS was observed in the validation cohort. The NAIDS may be a useful tool for donor pancreas selection in clinical practice. Apart from its utility in clinical decision making, the NAIDS may also be used in a research setting as a standardized measurement of pancreas quality.

Original language	English (US)
Pages (from-to)	1515-1523
Number of pages	9
Journal	Cell transplantation
Volume	25
Issue number	8
DOIs	https://doi.org/10.3727/096368916X691141
State	Published - 2016

Bibliographical note

Publisher Copyright:
© 2016 Cognizant, LLC.

Keywords

Islet isolation
Islet transplantation
Organ donor
Pancreas

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Wang, L. J., Kin, T., O’Gorman, D., Shapiro, A. M. J., Naziruddin, B., Takita, M., Levy, M. F., Posselt, A. M., Szot, G. L., Savari, O., Barbaro, B., McGarrigle, J., Yeh, C., Oberholzer, J., Lei, J., Chen, T., Lian, M., Markmann, J. F., Alvarez, A., ... Witkowski, P. (2016). A multicenter study: North american islet donor score in donor pancreas selection for human islet isolation for transplantation. Cell transplantation, 25(8), 1515-1523. https://doi.org/10.3727/096368916X691141

Wang, LJ, Kin, T, O’Gorman, D, Shapiro, AMJ, Naziruddin, B, Takita, M, Levy, MF, Posselt, AM, Szot, GL, Savari, O, Barbaro, B, McGarrigle, J, Yeh, C, Oberholzer, J, Lei, J, Chen, T, Lian, M, Markmann, JF, Alvarez, A, Linetsky, E, Ricordi, C, Balamurugan, AN, Loganathan, G, Wilhelm, JJ, Hering, BJ, Bottino, R, Trucco, M, Liu, C, Min, Z, Li, Y, Naji, A, Fernandez, LA, Ziemelis, M, Danobeitia, JS, Millis, JM & Witkowski, P 2016, 'A multicenter study: North american islet donor score in donor pancreas selection for human islet isolation for transplantation', Cell transplantation, vol. 25, no. 8, pp. 1515-1523. https://doi.org/10.3727/096368916X691141

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title = "A multicenter study: North american islet donor score in donor pancreas selection for human islet isolation for transplantation",

abstract = "Selection of an optimal donor pancreas is the first key task for successful islet isolation. We conducted a retrospective multicenter study in 11 centers in North America to develop an islet donor scoring system using donor variables. The data set consisting of 1,056 deceased donors was used for development of a scoring system to predict islet isolation success (defined as postpurification islet yield >400,000 islet equivalents). With the aid of univariate logistic regression analyses, we developed the North American Islet Donor Score (NAIDS) ranging from 0 to 100 points. The c index in the development cohort was 0.73 (95% confidence interval 0.70–0.76). The success rate increased proportionally as the NAIDS increased, from 6.8% success in the NAIDS < 50 points to 53.7% success in the NAIDS ≥ 80 points. We further validated the NAIDS using a separate set of data consisting of 179 islet isolations. A comparable outcome of the NAIDS was observed in the validation cohort. The NAIDS may be a useful tool for donor pancreas selection in clinical practice. Apart from its utility in clinical decision making, the NAIDS may also be used in a research setting as a standardized measurement of pancreas quality.",

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author = "Wang, {Ling Jia} and Tatsuya Kin and Doug O{\textquoteright}Gorman and Shapiro, {A. M James} and Bashoo Naziruddin and Morihito Takita and Levy, {Marlon F.} and Posselt, {Andrew M.} and Szot, {Gregory L.} and Omid Savari and Barbara Barbaro and James McGarrigle and Chunchieh Yeh and Jose Oberholzer and Ji Lei and Tao Chen and Moh Lian and Markmann, {James F.} and Alejandro Alvarez and Elina Linetsky and Camillo Ricordi and Balamurugan, {A. N.} and Gopalakrishnan Loganathan and Wilhelm, {Joshua J.} and Hering, {Bernhard J.} and Rita Bottino and Massimo Trucco and Chengyang Liu and Zaw Min and Yanjing Li and Ali Naji and Fernandez, {Luis A.} and Martynas Ziemelis and Danobeitia, {Juan S.} and Millis, {J. Michael} and Piotr Witkowski",

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year = "2016",

doi = "10.3727/096368916X691141",

language = "English (US)",

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AU - Wang, Ling Jia

AU - Kin, Tatsuya

AU - O’Gorman, Doug

AU - Shapiro, A. M James

AU - Naziruddin, Bashoo

AU - Takita, Morihito

AU - Levy, Marlon F.

AU - Posselt, Andrew M.

AU - Szot, Gregory L.

AU - Savari, Omid

AU - Barbaro, Barbara

AU - McGarrigle, James

AU - Yeh, Chunchieh

AU - Oberholzer, Jose

AU - Lei, Ji

AU - Chen, Tao

AU - Lian, Moh

AU - Markmann, James F.

AU - Alvarez, Alejandro

AU - Linetsky, Elina

AU - Ricordi, Camillo

AU - Balamurugan, A. N.

AU - Loganathan, Gopalakrishnan

AU - Wilhelm, Joshua J.

AU - Hering, Bernhard J.

AU - Bottino, Rita

AU - Trucco, Massimo

AU - Liu, Chengyang

AU - Min, Zaw

AU - Li, Yanjing

AU - Naji, Ali

AU - Fernandez, Luis A.

AU - Ziemelis, Martynas

AU - Danobeitia, Juan S.

AU - Millis, J. Michael

AU - Witkowski, Piotr

PY - 2016

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N2 - Selection of an optimal donor pancreas is the first key task for successful islet isolation. We conducted a retrospective multicenter study in 11 centers in North America to develop an islet donor scoring system using donor variables. The data set consisting of 1,056 deceased donors was used for development of a scoring system to predict islet isolation success (defined as postpurification islet yield >400,000 islet equivalents). With the aid of univariate logistic regression analyses, we developed the North American Islet Donor Score (NAIDS) ranging from 0 to 100 points. The c index in the development cohort was 0.73 (95% confidence interval 0.70–0.76). The success rate increased proportionally as the NAIDS increased, from 6.8% success in the NAIDS < 50 points to 53.7% success in the NAIDS ≥ 80 points. We further validated the NAIDS using a separate set of data consisting of 179 islet isolations. A comparable outcome of the NAIDS was observed in the validation cohort. The NAIDS may be a useful tool for donor pancreas selection in clinical practice. Apart from its utility in clinical decision making, the NAIDS may also be used in a research setting as a standardized measurement of pancreas quality.

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A multicenter study: North american islet donor score in donor pancreas selection for human islet isolation for transplantation

Abstract

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