A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19

Mark Klein; Vinh Dao; Fatima Khan

doi:10.1177/10760296211051764

A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19

Mark Klein, Vinh Dao, Fatima Khan

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the nature of platelet activating factor and emphasizes the similarities between the physiological effects of platelet activating factor and the clinical complications of severe COVID-19.

Original language	English (US)
Journal	Clinical and Applied Thrombosis/Hemostasis
Volume	27
DOIs	https://doi.org/10.1177/10760296211051764
State	Published - 2021

Bibliographical note

Funding Information:
MK, VD, and FM are all employees of the Minneapolis VA Healthcare System. This material is based upon work supported by the Department of Veterans Affairs (specifically the Veterans Health Administration). This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Funding Information:
MK, VD, and FM are all employees of the Minneapolis VA Healthcare System. This material is based upon work supported by the Department of Veterans Affairs (specifically the Veterans Health Administration).

Publisher Copyright:
© The Author(s) 2021.

Keywords

COVID-19
platelet activating factor
thrombosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19",

abstract = "The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the nature of platelet activating factor and emphasizes the similarities between the physiological effects of platelet activating factor and the clinical complications of severe COVID-19.",

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AU - Dao, Vinh

AU - Khan, Fatima

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Y1 - 2021

N2 - The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the nature of platelet activating factor and emphasizes the similarities between the physiological effects of platelet activating factor and the clinical complications of severe COVID-19.

AB - The precise mechanisms of pathology in severe COVID-19 remains elusive. Current evidence suggests that inflammatory mediators are responsible for the manifestation of clinical symptoms that precedes a fatal response to infection. This review examines the nature of platelet activating factor and emphasizes the similarities between the physiological effects of platelet activating factor and the clinical complications of severe COVID-19.

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KW - thrombosis

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ER -

A Review of Platelet-Activating Factor As a Potential Contributor to Morbidity and Mortality Associated with Severe COVID-19

Abstract

Bibliographical note

Keywords

UN SDGs

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