Abstract
The mechanisms of action of immunological adjuvants were studied using a system in which the behavior of adoptively transferred CD4+ T-cell receptor transgenic T-cells could be directly monitored following antigen administration. These studies revealed that adjuvant-induced inflammatory cytokines promote immunity by enhancing the clonal expansion, persistence and differentiation of antigen-activated CD4+ T-cells.
Original language | English (US) |
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Pages (from-to) | 23-31 |
Number of pages | 9 |
Journal | Agents and Actions Supplements |
Volume | 49 |
State | Published - 1997 |