TY - JOUR
T1 - A sperm cytoskeletal protein that signals oocyte meiotic maturation and ovulation
AU - Miller, M. A.
AU - Nguyen, V. Q.
AU - Lee, M. H.
AU - Kosinski, M.
AU - Schedl, T.
AU - Caprioli, R. M.
AU - Greenstein, D.
PY - 2001/3/16
Y1 - 2001/3/16
N2 - Caenorhabditis elegans oocytes, like those of most animals, arrest during meiotic prophase. Sperm promote the resumption of meiosis (maturation) and contraction of smooth muscle-like gonadal sheath cells, which are required for ovulation. We show that the major sperm cytoskeletal protein (MSP) is a bipartite signal for oocyte maturation and sheath contraction. MSP also functions in sperm locomotion, playing a role analogous to actin. Thus, during evolution, MSP has acquired extracellular signaling and intracellular cytoskeletal functions for reproduction. Proteins with MSP-like domains are found in plants, fungi, and other animals, suggesting that related signaling functions may exist in other phyla.
AB - Caenorhabditis elegans oocytes, like those of most animals, arrest during meiotic prophase. Sperm promote the resumption of meiosis (maturation) and contraction of smooth muscle-like gonadal sheath cells, which are required for ovulation. We show that the major sperm cytoskeletal protein (MSP) is a bipartite signal for oocyte maturation and sheath contraction. MSP also functions in sperm locomotion, playing a role analogous to actin. Thus, during evolution, MSP has acquired extracellular signaling and intracellular cytoskeletal functions for reproduction. Proteins with MSP-like domains are found in plants, fungi, and other animals, suggesting that related signaling functions may exist in other phyla.
UR - http://www.scopus.com/inward/record.url?scp=0035896390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035896390&partnerID=8YFLogxK
U2 - 10.1126/science.1057586
DO - 10.1126/science.1057586
M3 - Article
C2 - 11251118
AN - SCOPUS:0035896390
SN - 0036-8075
VL - 291
SP - 2144
EP - 2147
JO - Science
JF - Science
IS - 5511
ER -