TY - JOUR
T1 - A tandem cascade cyclization-electrophilic aromatic substitution
T2 - Application in the total synthesis of (+)-angelichalcone
AU - Topczewski, Joseph J.
AU - Callahan, Michael P.
AU - Neighbors, Jeffrey D.
AU - Wiemer, David F.
PY - 2009/10/21
Y1 - 2009/10/21
N2 - (Chemical Equation Presented) When cascade cyclizations initiated by Lewis acid-mediated opening of an epoxide are terminated through reaction with a MOM-protected phenol, a tandem electrophilic aromatic substitution can be obtained. This highly regioselective tandem process has been employed in the first synthesis of (+)-angelichalcone.
AB - (Chemical Equation Presented) When cascade cyclizations initiated by Lewis acid-mediated opening of an epoxide are terminated through reaction with a MOM-protected phenol, a tandem electrophilic aromatic substitution can be obtained. This highly regioselective tandem process has been employed in the first synthesis of (+)-angelichalcone.
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U2 - 10.1021/ja906468v
DO - 10.1021/ja906468v
M3 - Article
C2 - 19824722
AN - SCOPUS:70350070379
SN - 0002-7863
VL - 131
SP - 14630
EP - 14631
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 41
ER -