Activation of the transcription factor gli1 by wnt signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

Ikuo Nakamura; Maite G. Fernandez-Barrena; Maria C. Ortiz-Ruiz; Luciana L. Almada; Chunling Hu; Sherine F. Elsawa; Lisa D. Mills; Paola A. Romecin; Kadra H. Gulaid; Catherine D. Moser; Jing Jing Han; Anne Vrabel; Eric A. Hanse; Nicholas A. Akogyeram; Jeffrey H. Albrecht; Satdarshan P S Monga; Schuyler O. Sanderson; Jesus Prieto; Lewis R. Roberts; Martin E. Fernandez-Zapico

doi:10.1074/jbc.M112.443440

Activation of the transcription factor gli1 by wnt signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

Ikuo Nakamura, Maite G. Fernandez-Barrena, Maria C. Ortiz-Ruiz, Luciana L. Almada, Chunling Hu, Sherine F. Elsawa, Lisa D. Mills, Paola A. Romecin, Kadra H. Gulaid, Catherine D. Moser, Jing Jing Han, Anne Vrabel, Eric A. Hanse, Nicholas A. Akogyeram, Jeffrey H. Albrecht, Satdarshan P S Monga, Schuyler O. Sanderson, Jesus Prieto, Lewis R. Roberts, Martin E. Fernandez-Zapico

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Tissue regeneration is a complex process involving a network of ligand-activated pathways. Results: The sulfatase SULF2 modulates cell proliferation and organ growth through a WNT-dependent activation of the transcription factor GLI1. Conclusion: Together, these data define a novel cascade regulating tissue regeneration. Significance: The knowledge derived from this study will contribute to the understanding of the molecular mechanisms modulating regeneration and organogenesis.

Original language	English (US)
Pages (from-to)	21389-21398
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	29
DOIs	https://doi.org/10.1074/jbc.M112.443440
State	Published - Jul 19 2013

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Nakamura, I., Fernandez-Barrena, M. G., Ortiz-Ruiz, M. C., Almada, L. L., Hu, C., Elsawa, S. F., Mills, L. D., Romecin, P. A., Gulaid, K. H., Moser, C. D., Han, J. J., Vrabel, A., Hanse, E. A., Akogyeram, N. A., Albrecht, J. H., Monga, S. P. S., Sanderson, S. O., Prieto, J., Roberts, L. R., & Fernandez-Zapico, M. E. (2013). Activation of the transcription factor gli1 by wnt signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration. Journal of Biological Chemistry, 288(29), 21389-21398. https://doi.org/10.1074/jbc.M112.443440

Nakamura, I, Fernandez-Barrena, MG, Ortiz-Ruiz, MC, Almada, LL, Hu, C, Elsawa, SF, Mills, LD, Romecin, PA, Gulaid, KH, Moser, CD, Han, JJ, Vrabel, A, Hanse, EA, Akogyeram, NA, Albrecht, JH, Monga, SPS, Sanderson, SO, Prieto, J, Roberts, LR & Fernandez-Zapico, ME 2013, 'Activation of the transcription factor gli1 by wnt signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration', Journal of Biological Chemistry, vol. 288, no. 29, pp. 21389-21398. https://doi.org/10.1074/jbc.M112.443440

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title = "Activation of the transcription factor gli1 by wnt signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration",

abstract = "Background: Tissue regeneration is a complex process involving a network of ligand-activated pathways. Results: The sulfatase SULF2 modulates cell proliferation and organ growth through a WNT-dependent activation of the transcription factor GLI1. Conclusion: Together, these data define a novel cascade regulating tissue regeneration. Significance: The knowledge derived from this study will contribute to the understanding of the molecular mechanisms modulating regeneration and organogenesis.",

author = "Ikuo Nakamura and Fernandez-Barrena, {Maite G.} and Ortiz-Ruiz, {Maria C.} and Almada, {Luciana L.} and Chunling Hu and Elsawa, {Sherine F.} and Mills, {Lisa D.} and Romecin, {Paola A.} and Gulaid, {Kadra H.} and Moser, {Catherine D.} and Han, {Jing Jing} and Anne Vrabel and Hanse, {Eric A.} and Akogyeram, {Nicholas A.} and Albrecht, {Jeffrey H.} and Monga, {Satdarshan P S} and Sanderson, {Schuyler O.} and Jesus Prieto and Roberts, {Lewis R.} and Fernandez-Zapico, {Martin E.}",

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AU - Nakamura, Ikuo

AU - Fernandez-Barrena, Maite G.

AU - Ortiz-Ruiz, Maria C.

AU - Almada, Luciana L.

AU - Hu, Chunling

AU - Elsawa, Sherine F.

AU - Mills, Lisa D.

AU - Romecin, Paola A.

AU - Gulaid, Kadra H.

AU - Moser, Catherine D.

AU - Han, Jing Jing

AU - Vrabel, Anne

AU - Hanse, Eric A.

AU - Akogyeram, Nicholas A.

AU - Albrecht, Jeffrey H.

AU - Monga, Satdarshan P S

AU - Sanderson, Schuyler O.

AU - Prieto, Jesus

AU - Roberts, Lewis R.

AU - Fernandez-Zapico, Martin E.

PY - 2013/7/19

Y1 - 2013/7/19

N2 - Background: Tissue regeneration is a complex process involving a network of ligand-activated pathways. Results: The sulfatase SULF2 modulates cell proliferation and organ growth through a WNT-dependent activation of the transcription factor GLI1. Conclusion: Together, these data define a novel cascade regulating tissue regeneration. Significance: The knowledge derived from this study will contribute to the understanding of the molecular mechanisms modulating regeneration and organogenesis.

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Activation of the transcription factor gli1 by wnt signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

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