Acute Hemodynamic Effects of Biventricular Pacing After Left Ventricular Assist Device

Joanna M. Joly; Deepak Acharya; Harish Doppalapudi; G. Neal Kay; Chee Paul Lin; William R. Maddox; H. Thomas McElderry; Salpy V. Pamboukian; Vance J. Plumb; Indranee N. Rajapreyar; José A. Tallaj; Takumi Yamada; Vineet Kumar

doi:10.1016/j.cardfail.2018.09.008

Acute Hemodynamic Effects of Biventricular Pacing After Left Ventricular Assist Device

Joanna M. Joly, Deepak Acharya, Harish Doppalapudi, G. Neal Kay, Chee Paul Lin, William R. Maddox, H. Thomas McElderry, Salpy V. Pamboukian, Vance J. Plumb, Indranee N. Rajapreyar, José A. Tallaj, Takumi Yamada, Vineet Kumar

Research output: Contribution to journal › Letter › peer-review

3 Scopus citations

Abstract

Background: Despite cardiac resynchronization therapy (CRT), some patients with heart failure progress and undergo left ventricular assist device (LVAD) implantation. Management of CRT after LVAD implantation has not been well studied. The purpose of this study was to determine whether RV pacing or biventricular pacing measurably affects acute hemodynamics in patients with an LVAD and a CRT device. Methods and Results: Seven patients with CRT and LVAD underwent right heart catheterization. Pressures and oximetry were measured and LVAD parameters were recorded during 3 different conditions: RV pacing alone, biventricular pacing, and intrinsic atrioventricular conduction. Paired t tests were used to evaluate changes within subjects. There were no significant changes in right atrial pressure, pulmonary arterial pressures, pulmonary capillary wedge pressure, cardiac index, or any LVAD parameter (P >.05). Conclusions: Our data suggest that CRT probably has no acute hemodynamic effect in patients with LVADs, but further study is needed.

Original language	English (US)
Pages (from-to)	716-718
Number of pages	3
Journal	Journal of cardiac failure
Volume	24
Issue number	10
DOIs	https://doi.org/10.1016/j.cardfail.2018.09.008
State	Published - Oct 2018
Externally published	Yes

Bibliographical note

Funding Information:
Statistical analysis reported in this publication was partially supported by the National Center for Advancing Translational Sciences of the National Institutes of Health , under award number UL1TR001417 .

Publisher Copyright:
© 2018

Keywords

Hemodynamics
biventricular pacing
cardiac resynchronization therapy
heart failure
left ventricular assist device
right heart catheterization

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Joly, J. M., Acharya, D., Doppalapudi, H., Kay, G. N., Lin, C. P., Maddox, W. R., McElderry, H. T., Pamboukian, S. V., Plumb, V. J., Rajapreyar, I. N., Tallaj, J. A., Yamada, T., & Kumar, V. (2018). Acute Hemodynamic Effects of Biventricular Pacing After Left Ventricular Assist Device. Journal of cardiac failure, 24(10), 716-718. https://doi.org/10.1016/j.cardfail.2018.09.008

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title = "Acute Hemodynamic Effects of Biventricular Pacing After Left Ventricular Assist Device",

abstract = "Background: Despite cardiac resynchronization therapy (CRT), some patients with heart failure progress and undergo left ventricular assist device (LVAD) implantation. Management of CRT after LVAD implantation has not been well studied. The purpose of this study was to determine whether RV pacing or biventricular pacing measurably affects acute hemodynamics in patients with an LVAD and a CRT device. Methods and Results: Seven patients with CRT and LVAD underwent right heart catheterization. Pressures and oximetry were measured and LVAD parameters were recorded during 3 different conditions: RV pacing alone, biventricular pacing, and intrinsic atrioventricular conduction. Paired t tests were used to evaluate changes within subjects. There were no significant changes in right atrial pressure, pulmonary arterial pressures, pulmonary capillary wedge pressure, cardiac index, or any LVAD parameter (P >.05). Conclusions: Our data suggest that CRT probably has no acute hemodynamic effect in patients with LVADs, but further study is needed.",

keywords = "Hemodynamics, biventricular pacing, cardiac resynchronization therapy, heart failure, left ventricular assist device, right heart catheterization",

author = "Joly, {Joanna M.} and Deepak Acharya and Harish Doppalapudi and Kay, {G. Neal} and Lin, {Chee Paul} and Maddox, {William R.} and McElderry, {H. Thomas} and Pamboukian, {Salpy V.} and Plumb, {Vance J.} and Rajapreyar, {Indranee N.} and Tallaj, {Jos{\'e} A.} and Takumi Yamada and Vineet Kumar",

note = "Funding Information: Statistical analysis reported in this publication was partially supported by the National Center for Advancing Translational Sciences of the National Institutes of Health , under award number UL1TR001417 . Publisher Copyright: {\textcopyright} 2018",

year = "2018",

month = oct,

doi = "10.1016/j.cardfail.2018.09.008",

language = "English (US)",

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T1 - Acute Hemodynamic Effects of Biventricular Pacing After Left Ventricular Assist Device

AU - Joly, Joanna M.

AU - Acharya, Deepak

AU - Doppalapudi, Harish

AU - Kay, G. Neal

AU - Lin, Chee Paul

AU - Maddox, William R.

AU - McElderry, H. Thomas

AU - Pamboukian, Salpy V.

AU - Plumb, Vance J.

AU - Rajapreyar, Indranee N.

AU - Tallaj, José A.

AU - Yamada, Takumi

AU - Kumar, Vineet

N1 - Funding Information: Statistical analysis reported in this publication was partially supported by the National Center for Advancing Translational Sciences of the National Institutes of Health , under award number UL1TR001417 . Publisher Copyright: © 2018

PY - 2018/10

Y1 - 2018/10

N2 - Background: Despite cardiac resynchronization therapy (CRT), some patients with heart failure progress and undergo left ventricular assist device (LVAD) implantation. Management of CRT after LVAD implantation has not been well studied. The purpose of this study was to determine whether RV pacing or biventricular pacing measurably affects acute hemodynamics in patients with an LVAD and a CRT device. Methods and Results: Seven patients with CRT and LVAD underwent right heart catheterization. Pressures and oximetry were measured and LVAD parameters were recorded during 3 different conditions: RV pacing alone, biventricular pacing, and intrinsic atrioventricular conduction. Paired t tests were used to evaluate changes within subjects. There were no significant changes in right atrial pressure, pulmonary arterial pressures, pulmonary capillary wedge pressure, cardiac index, or any LVAD parameter (P >.05). Conclusions: Our data suggest that CRT probably has no acute hemodynamic effect in patients with LVADs, but further study is needed.

AB - Background: Despite cardiac resynchronization therapy (CRT), some patients with heart failure progress and undergo left ventricular assist device (LVAD) implantation. Management of CRT after LVAD implantation has not been well studied. The purpose of this study was to determine whether RV pacing or biventricular pacing measurably affects acute hemodynamics in patients with an LVAD and a CRT device. Methods and Results: Seven patients with CRT and LVAD underwent right heart catheterization. Pressures and oximetry were measured and LVAD parameters were recorded during 3 different conditions: RV pacing alone, biventricular pacing, and intrinsic atrioventricular conduction. Paired t tests were used to evaluate changes within subjects. There were no significant changes in right atrial pressure, pulmonary arterial pressures, pulmonary capillary wedge pressure, cardiac index, or any LVAD parameter (P >.05). Conclusions: Our data suggest that CRT probably has no acute hemodynamic effect in patients with LVADs, but further study is needed.

KW - Hemodynamics

KW - biventricular pacing

KW - cardiac resynchronization therapy

KW - heart failure

KW - left ventricular assist device

KW - right heart catheterization

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ER -

Acute Hemodynamic Effects of Biventricular Pacing After Left Ventricular Assist Device

Abstract

Bibliographical note

Keywords

UN SDGs

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