TY - CHAP
T1 - Acute kidney injury following cardiopulmonary bypass
AU - Wheeler, D. S.
AU - Dent, C. L.
AU - Devarajan, P.
AU - Kooy, N. W.
PY - 2009
Y1 - 2009
N2 - Core Messages: Cardiopulmonary bypass is a significant risk factor for acute kidney injury (AKI) in children with congenital heart disease. AKI is a significant and independent risk factor for increased morbidity and mortality in critically ill patients. The traditional definitions of acute renal failure that rely on changes in serum creatinine alone are no longer valid, as even small increases in serum creatinine are associated with excess morbidity and mortality in critically ill patients. The concentrations of urinary NGAL, IL-18, and KIM-1, and serum NGAL and cystatin C are emerging as novel, early biomarkers of AKI in children following cardiopulmonary bypass. The treatment of AKI is largely supportive, though early recognition is important. Timing of treatment (i.e., renal replacement therapy) may be crucial to assure the best possible outcome.
AB - Core Messages: Cardiopulmonary bypass is a significant risk factor for acute kidney injury (AKI) in children with congenital heart disease. AKI is a significant and independent risk factor for increased morbidity and mortality in critically ill patients. The traditional definitions of acute renal failure that rely on changes in serum creatinine alone are no longer valid, as even small increases in serum creatinine are associated with excess morbidity and mortality in critically ill patients. The concentrations of urinary NGAL, IL-18, and KIM-1, and serum NGAL and cystatin C are emerging as novel, early biomarkers of AKI in children following cardiopulmonary bypass. The treatment of AKI is largely supportive, though early recognition is important. Timing of treatment (i.e., renal replacement therapy) may be crucial to assure the best possible outcome.
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U2 - 10.1007/978-3-540-74425-2_19
DO - 10.1007/978-3-540-74425-2_19
M3 - Chapter
AN - SCOPUS:84890145444
SN - 9783540744238
SP - 262
EP - 273
BT - Pediatric Nephrology in the ICU
PB - Springer Berlin Heidelberg
ER -