TY - JOUR
T1 - Adoptive protection from experimental myasthenia gravis with T cells from mice treated nasally with acetylcholine receptor epitopes
AU - Monfardini, Cristina
AU - Milani, Monica
AU - Ostlie, Norma
AU - Wang, Wei
AU - Karachunski, Peter I.
AU - Okita, David K.
AU - Lindstrom, Jon
AU - Conti-Fine, Bianca M.
N1 - Funding Information:
This work was supported by the NINCDS grant NS 23919 (to BMC-F).
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2002
Y1 - 2002
N2 - Nasal administration of synthetic CD4+ epitopes of the acetylcholine receptor (AChR) prevents experimental myasthenia gravis (EMG) in C57Bl/6 mice, but not in IL4-deficient C57Bl/6 (IL4-/-) mice. Here we verify that nasal tolerance requires IL4, by showing that CD4+ cells from C57Bl/6 mice treated nasally with a pool of AChR CD4+ epitopes protected IL4-/- mice from EMG and caused a reduced production of anti-AChR antibody. CD4+ cells from C57Bl/6 mice treated with unrelated peptides or sham-treated did not induce protection. CD4+ cells from C57Bl/6 mice treated with just one AChR peptide protected IL4-/- mice from EMG without affecting antibody synthesis.
AB - Nasal administration of synthetic CD4+ epitopes of the acetylcholine receptor (AChR) prevents experimental myasthenia gravis (EMG) in C57Bl/6 mice, but not in IL4-deficient C57Bl/6 (IL4-/-) mice. Here we verify that nasal tolerance requires IL4, by showing that CD4+ cells from C57Bl/6 mice treated nasally with a pool of AChR CD4+ epitopes protected IL4-/- mice from EMG and caused a reduced production of anti-AChR antibody. CD4+ cells from C57Bl/6 mice treated with unrelated peptides or sham-treated did not induce protection. CD4+ cells from C57Bl/6 mice treated with just one AChR peptide protected IL4-/- mice from EMG without affecting antibody synthesis.
KW - Autoimmunity
KW - Epitopes
KW - Experimental myasthenia gravis
KW - T lymphocytes
KW - Tolerance
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U2 - 10.1016/S0165-5728(01)00454-4
DO - 10.1016/S0165-5728(01)00454-4
M3 - Article
C2 - 11880157
AN - SCOPUS:0036187501
SN - 0165-5728
VL - 123
SP - 123
EP - 134
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -