Abstract
Mitochondria are both morphologically and functionally diverse, and this variety is thought to have important biological ramifications. The development of methods to probe the properties of individual mitochondria is therefore of utmost importance. Recent advances have been made using in situ microscopy techniques and methods to investigate isolated mitochondria, including flow cytometry, capillary electrophoresis, patch-clamping and optical trapping. Such techniques have been used to study metabolism, mitochondrial calcium homeostasis, mitochondrial membrane potential, apoptosis, and other properties.
Original language | English (US) |
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Pages (from-to) | 35-41 |
Number of pages | 7 |
Journal | Current opinion in biotechnology |
Volume | 14 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2003 |
Bibliographical note
Funding Information:KMF acknowledges initial support from a National Institute of Health Chemistry/Biology Interface Training Grant (Grant GM08700). EAA is supported by the National Institute of Health (Grants R01 GM61969 and RO1 AG20866).