Age-related changes in CD8 T cell homeostasis and immunity to infection

Janko Nikolich-Žugich; Gang Li; Jennifer L. Uhrlaub; Kristin R. Renkema; Megan J. Smithey

doi:10.1016/j.smim.2012.04.009

Age-related changes in CD8 T cell homeostasis and immunity to infection

Janko Nikolich-Žugich, Gang Li, Jennifer L. Uhrlaub, Kristin R. Renkema, Megan J. Smithey

Research output: Contribution to journal › Review article › peer-review

102 Scopus citations

Abstract

Studies of CD8 T cell responses to vaccination or infection with various pathogens in both animal models and human subjects have revealed a markedly consistent array of age-related defects. In general, recent work shows that aged CD8 T cell responses are decreased in magnitude, and show poor differentiation into effector cells, with a reduced arsenal of effector functions. Here we review potential mechanisms underlying these defects. We specifically address phenotypic and numeric changes to the naïve CD8 T cell precursor pool, the impact of persistent viral infection(s) and inflammation, and contributions of the aging environment in which these cells are activated.

Original language	English (US)
Pages (from-to)	356-364
Number of pages	9
Journal	Seminars in Immunology
Volume	24
Issue number	5
DOIs	https://doi.org/10.1016/j.smim.2012.04.009
State	Published - Oct 2012
Externally published	Yes

Bibliographical note

Funding Information:
We wish to thank the past and present members of the Nikolich laboratory for support and helpful discussions. Supported by NIH awards AG020719 , AG035309 , AI081680 and N01 AI 00017 .

Keywords

Aging
CD8 T cells
Homeostasis
Immunity
Infection

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title = "Age-related changes in CD8 T cell homeostasis and immunity to infection",

abstract = "Studies of CD8 T cell responses to vaccination or infection with various pathogens in both animal models and human subjects have revealed a markedly consistent array of age-related defects. In general, recent work shows that aged CD8 T cell responses are decreased in magnitude, and show poor differentiation into effector cells, with a reduced arsenal of effector functions. Here we review potential mechanisms underlying these defects. We specifically address phenotypic and numeric changes to the na{\"i}ve CD8 T cell precursor pool, the impact of persistent viral infection(s) and inflammation, and contributions of the aging environment in which these cells are activated.",

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AU - Renkema, Kristin R.

AU - Smithey, Megan J.

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Age-related changes in CD8 T cell homeostasis and immunity to infection

Abstract

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Keywords

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