Agreement between self-reported and objective measures of sleep in people with HIV and lifestyle-similar HIV-negative individuals

Davide De Francesco; Caroline A. Sabin; Alan Winston; Patrick W.G. Mallon; Jane Anderson; Marta Boffito; Nicki D. Doyle; Lewis Haddow; Frank A. Post; Jaime H. Vera; Memory Sachikonye; Susan Redline; Ken M. Kunisaki

doi:10.1097/QAD.0000000000002852

Agreement between self-reported and objective measures of sleep in people with HIV and lifestyle-similar HIV-negative individuals

Davide De Francesco, Caroline A. Sabin, Alan Winston, Patrick W.G. Mallon, Jane Anderson, Marta Boffito, Nicki D. Doyle, Lewis Haddow, Frank A. Post, Jaime H. Vera, Memory Sachikonye, Susan Redline, Ken M. Kunisaki

Medicine - Veteran's Administration Medical Center

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Objectives:The aim of this study was to evaluate the agreement between self-reported sleep measures and insomnia with objectively measured sleep parameters in people with HIV (PWH) and HIV-negative individuals.Design:A cross-sectional analysis of PWH and lifestyle-similar HIV-negative individuals.Methods:Self-reported measures included time spent in bed, sleep onset latency and a validated insomnia questionnaire. Objective measures were assessed via 7-days/nights of actigraphy data to determine average and intra-individual variability of several sleep measures (including time spent in bed and onset latency). Spearman's correlation coefficient and Cohen's κ were used to assess the agreement between self-reported and actigraphy-assessed measures. Associations between insomnia and actigraphy-assessed sleep parameters were evaluated using partial least-square discriminant analysis (PLS-DA).Results:We found fair correlation between self-reported and actigraphy-assessed time spent in bed in 342 PWH (r_s = 0.46) and 119 HIV-negative individuals (r_s = 0.48). Among PWH, the correlation did not differ by age, education, depressive symptoms and self-reported insomnia (all P > 0.05), but was stronger in men (P = 0.05) and in those with a BMI of at least 25 kg/m²(P < 0.001). Agreement between self-reported and actigraphy-assessed sleep onset latency was poor in both PWH (κ = 0.002, P = 0.49) and HIV-negative individuals (κ = 0.009, P = 0.65). According to PLS-DA, self-reported insomnia most strongly correlated with intra-individual variability of sleep duration, movement index and efficiency.Conclusion:We report poor-to-fair agreement between self-reported and actigraphy-assessed sleep measures in PWH. Insomnia symptoms correlated with regularity of sleep duration, quality and efficiency. These findings highlight the importance of both patient-reported and objective measures of daily sleep variation, for better understanding sleep disorders in PWH.

Original language	English (US)
Pages (from-to)	1051-1060
Number of pages	10
Journal	AIDS
Volume	35
Issue number	7
DOIs	https://doi.org/10.1097/QAD.0000000000002852
State	Published - Jun 1 2021

Bibliographical note

Funding Information:
POPPY-Sleep Management Team: Ken Kunisaki, Susan Redline, Alan Winston, Caroline Sabin, Paddy Mallon, Nicki Doyle, Amalia Ndoutoumou. POPPY-Sleep Sleep Reading Centre Team: Emily Kaplan, Dan Mobley, Michael Rueschman, Michelle Reid (Brigham and Women's Hospital, Boston/USA). POPPY-Sleep methodology/statistics/analysis: Caroline Sabin, Davide De Francesco, Mike Rueschman. POPPY-Sleep Sites and Trials Unit: Caldecot Centre, King's College Hospital (Frank Post, Beatriz Santana Suárez, Lucy Campbell); Department of Infection and Population Health, University College London (Lewis Haddow, Michelle Beynon, Abigail Severn, Anna-Lena Salz, Hinal Lukha); Elton John Centre, Brighton and Sussex University Hospital (Jaime Vera, Rebecca Gleig, Sarah Kirk); HIV Molecular Research Group, School of Medicine, University College Dublin (Paddy Mallon, Alan Macken, Sumesh Babu, Aoife McDermott); Homerton Sexual Health Services, Homerton University Hospital (Jane Anderson, Sambasivarao Pelluri, Anna Price); Imperial Clinical Trials Unit, Imperial College London (Amalia Ndoutoumou, Daphne Babalis); St. Mary's Hospital London, Imperial College Healthcare NHS Trust (Alan Winston, Felix Dransfield); St Stephen's Centre, Chelsea and Westminster Hospital (Marta Boffito, Michelle Anthonipillai, Peter Fernando, Shane Hardwick, Chido Chiwome, Candida Fernandez, Ana Milinkovic). POPPY-Sleep Funders: The POPPY-Sleep sub study is funded by the US National Heart, Lung, and Blood Institute (R01 HL131049); the main POPPY study is funded from investigator-initiated grants from BMS, Gilead Sciences, Janssen, MSD and ViiV Healthcare. We acknowledge the use of the NIHR/Wellcome Trust Clinical Research Facility at King's College Hospital. The research is also supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Imperial College Healthcare NHS Trust and Imperial College London.

Funding Information:
This study is funded by the US National Heart, Lung, and Blood Institute (R01 HL131049); by investigator-initiated grants from BMS, Gilead Sciences, Janssen, MSD and ViiV Healthcare; and by the NIHR Biomedical Research Centre.

Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.

Keywords

HIV
actigraphy
agreement
insomnia
sleep

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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De Francesco, D., Sabin, C. A., Winston, A., Mallon, P. W. G., Anderson, J., Boffito, M., Doyle, N. D., Haddow, L., Post, F. A., Vera, J. H., Sachikonye, M., Redline, S., & Kunisaki, K. M. (2021). Agreement between self-reported and objective measures of sleep in people with HIV and lifestyle-similar HIV-negative individuals. AIDS, 35(7), 1051-1060. https://doi.org/10.1097/QAD.0000000000002852

De Francesco, D, Sabin, CA, Winston, A, Mallon, PWG, Anderson, J, Boffito, M, Doyle, ND, Haddow, L, Post, FA, Vera, JH, Sachikonye, M, Redline, S & Kunisaki, KM 2021, 'Agreement between self-reported and objective measures of sleep in people with HIV and lifestyle-similar HIV-negative individuals', AIDS, vol. 35, no. 7, pp. 1051-1060. https://doi.org/10.1097/QAD.0000000000002852

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abstract = "Objectives:The aim of this study was to evaluate the agreement between self-reported sleep measures and insomnia with objectively measured sleep parameters in people with HIV (PWH) and HIV-negative individuals.Design:A cross-sectional analysis of PWH and lifestyle-similar HIV-negative individuals.Methods:Self-reported measures included time spent in bed, sleep onset latency and a validated insomnia questionnaire. Objective measures were assessed via 7-days/nights of actigraphy data to determine average and intra-individual variability of several sleep measures (including time spent in bed and onset latency). Spearman's correlation coefficient and Cohen's κ were used to assess the agreement between self-reported and actigraphy-assessed measures. Associations between insomnia and actigraphy-assessed sleep parameters were evaluated using partial least-square discriminant analysis (PLS-DA).Results:We found fair correlation between self-reported and actigraphy-assessed time spent in bed in 342 PWH (rs = 0.46) and 119 HIV-negative individuals (rs = 0.48). Among PWH, the correlation did not differ by age, education, depressive symptoms and self-reported insomnia (all P > 0.05), but was stronger in men (P = 0.05) and in those with a BMI of at least 25 kg/m2(P < 0.001). Agreement between self-reported and actigraphy-assessed sleep onset latency was poor in both PWH (κ = 0.002, P = 0.49) and HIV-negative individuals (κ = 0.009, P = 0.65). According to PLS-DA, self-reported insomnia most strongly correlated with intra-individual variability of sleep duration, movement index and efficiency.Conclusion:We report poor-to-fair agreement between self-reported and actigraphy-assessed sleep measures in PWH. Insomnia symptoms correlated with regularity of sleep duration, quality and efficiency. These findings highlight the importance of both patient-reported and objective measures of daily sleep variation, for better understanding sleep disorders in PWH.",

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month = jun,

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doi = "10.1097/QAD.0000000000002852",

language = "English (US)",

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TY - JOUR

T1 - Agreement between self-reported and objective measures of sleep in people with HIV and lifestyle-similar HIV-negative individuals

AU - De Francesco, Davide

AU - Sabin, Caroline A.

AU - Winston, Alan

AU - Mallon, Patrick W.G.

AU - Anderson, Jane

AU - Boffito, Marta

AU - Doyle, Nicki D.

AU - Haddow, Lewis

AU - Post, Frank A.

AU - Vera, Jaime H.

AU - Sachikonye, Memory

AU - Redline, Susan

AU - Kunisaki, Ken M.

N1 - Funding Information: POPPY-Sleep Management Team: Ken Kunisaki, Susan Redline, Alan Winston, Caroline Sabin, Paddy Mallon, Nicki Doyle, Amalia Ndoutoumou. POPPY-Sleep Sleep Reading Centre Team: Emily Kaplan, Dan Mobley, Michael Rueschman, Michelle Reid (Brigham and Women's Hospital, Boston/USA). POPPY-Sleep methodology/statistics/analysis: Caroline Sabin, Davide De Francesco, Mike Rueschman. POPPY-Sleep Sites and Trials Unit: Caldecot Centre, King's College Hospital (Frank Post, Beatriz Santana Suárez, Lucy Campbell); Department of Infection and Population Health, University College London (Lewis Haddow, Michelle Beynon, Abigail Severn, Anna-Lena Salz, Hinal Lukha); Elton John Centre, Brighton and Sussex University Hospital (Jaime Vera, Rebecca Gleig, Sarah Kirk); HIV Molecular Research Group, School of Medicine, University College Dublin (Paddy Mallon, Alan Macken, Sumesh Babu, Aoife McDermott); Homerton Sexual Health Services, Homerton University Hospital (Jane Anderson, Sambasivarao Pelluri, Anna Price); Imperial Clinical Trials Unit, Imperial College London (Amalia Ndoutoumou, Daphne Babalis); St. Mary's Hospital London, Imperial College Healthcare NHS Trust (Alan Winston, Felix Dransfield); St Stephen's Centre, Chelsea and Westminster Hospital (Marta Boffito, Michelle Anthonipillai, Peter Fernando, Shane Hardwick, Chido Chiwome, Candida Fernandez, Ana Milinkovic). POPPY-Sleep Funders: The POPPY-Sleep sub study is funded by the US National Heart, Lung, and Blood Institute (R01 HL131049); the main POPPY study is funded from investigator-initiated grants from BMS, Gilead Sciences, Janssen, MSD and ViiV Healthcare. We acknowledge the use of the NIHR/Wellcome Trust Clinical Research Facility at King's College Hospital. The research is also supported by the National Institute for Health Research (NIHR) Biomedical Research Centre based at Imperial College Healthcare NHS Trust and Imperial College London. Funding Information: This study is funded by the US National Heart, Lung, and Blood Institute (R01 HL131049); by investigator-initiated grants from BMS, Gilead Sciences, Janssen, MSD and ViiV Healthcare; and by the NIHR Biomedical Research Centre. Publisher Copyright: © 2021 Lippincott Williams and Wilkins. All rights reserved.

PY - 2021/6/1

Y1 - 2021/6/1

N2 - Objectives:The aim of this study was to evaluate the agreement between self-reported sleep measures and insomnia with objectively measured sleep parameters in people with HIV (PWH) and HIV-negative individuals.Design:A cross-sectional analysis of PWH and lifestyle-similar HIV-negative individuals.Methods:Self-reported measures included time spent in bed, sleep onset latency and a validated insomnia questionnaire. Objective measures were assessed via 7-days/nights of actigraphy data to determine average and intra-individual variability of several sleep measures (including time spent in bed and onset latency). Spearman's correlation coefficient and Cohen's κ were used to assess the agreement between self-reported and actigraphy-assessed measures. Associations between insomnia and actigraphy-assessed sleep parameters were evaluated using partial least-square discriminant analysis (PLS-DA).Results:We found fair correlation between self-reported and actigraphy-assessed time spent in bed in 342 PWH (rs = 0.46) and 119 HIV-negative individuals (rs = 0.48). Among PWH, the correlation did not differ by age, education, depressive symptoms and self-reported insomnia (all P > 0.05), but was stronger in men (P = 0.05) and in those with a BMI of at least 25 kg/m2(P < 0.001). Agreement between self-reported and actigraphy-assessed sleep onset latency was poor in both PWH (κ = 0.002, P = 0.49) and HIV-negative individuals (κ = 0.009, P = 0.65). According to PLS-DA, self-reported insomnia most strongly correlated with intra-individual variability of sleep duration, movement index and efficiency.Conclusion:We report poor-to-fair agreement between self-reported and actigraphy-assessed sleep measures in PWH. Insomnia symptoms correlated with regularity of sleep duration, quality and efficiency. These findings highlight the importance of both patient-reported and objective measures of daily sleep variation, for better understanding sleep disorders in PWH.

AB - Objectives:The aim of this study was to evaluate the agreement between self-reported sleep measures and insomnia with objectively measured sleep parameters in people with HIV (PWH) and HIV-negative individuals.Design:A cross-sectional analysis of PWH and lifestyle-similar HIV-negative individuals.Methods:Self-reported measures included time spent in bed, sleep onset latency and a validated insomnia questionnaire. Objective measures were assessed via 7-days/nights of actigraphy data to determine average and intra-individual variability of several sleep measures (including time spent in bed and onset latency). Spearman's correlation coefficient and Cohen's κ were used to assess the agreement between self-reported and actigraphy-assessed measures. Associations between insomnia and actigraphy-assessed sleep parameters were evaluated using partial least-square discriminant analysis (PLS-DA).Results:We found fair correlation between self-reported and actigraphy-assessed time spent in bed in 342 PWH (rs = 0.46) and 119 HIV-negative individuals (rs = 0.48). Among PWH, the correlation did not differ by age, education, depressive symptoms and self-reported insomnia (all P > 0.05), but was stronger in men (P = 0.05) and in those with a BMI of at least 25 kg/m2(P < 0.001). Agreement between self-reported and actigraphy-assessed sleep onset latency was poor in both PWH (κ = 0.002, P = 0.49) and HIV-negative individuals (κ = 0.009, P = 0.65). According to PLS-DA, self-reported insomnia most strongly correlated with intra-individual variability of sleep duration, movement index and efficiency.Conclusion:We report poor-to-fair agreement between self-reported and actigraphy-assessed sleep measures in PWH. Insomnia symptoms correlated with regularity of sleep duration, quality and efficiency. These findings highlight the importance of both patient-reported and objective measures of daily sleep variation, for better understanding sleep disorders in PWH.

KW - HIV

KW - actigraphy

KW - agreement

KW - insomnia

KW - sleep

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Agreement between self-reported and objective measures of sleep in people with HIV and lifestyle-similar HIV-negative individuals

Abstract

Bibliographical note

Keywords

UN SDGs

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