Abstract
Polyfluorinated aliphatic aldehydes react with 1-phenyl-3-methylpyrazole-5-one, 1-phenyl-3-methyl-5-amino (N, N-dimethylaminomethylenamino)pyrazole and 1-phenyl-3-aminopyrazole-5-one at room temperature in the absence of catalyst with formation of 4-(1-hydroxypolyfluoroalkyl)pyrazoles. Dehydration of 4-(1-hydroxypolyfluoroalkyl)pyrazoles with morpholinosulfur trifluoride generates 4-polyfluoroalkylidenepyrazoles, which are active dienophiles and react with 2,3-dimethylbutadiene and cyclopentadiene forming spirocyclic pyrazole derivatives.
Original language | English (US) |
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Pages (from-to) | 111-116 |
Number of pages | 6 |
Journal | Journal of Fluorine Chemistry |
Volume | 101 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2000 |
Keywords
- Alkylation
- Polyfluorinated aliphatic aldehyde
- Pyrazole