TY - JOUR
T1 - Alternative memory in the CD8 T cell lineage
AU - Lee, You Jeong
AU - Jameson, Stephen C.
AU - Hogquist, Kristin A.
N1 - Funding Information:
This work was supported by grants to K.A.H. (AI39560) and S.C.J. (AI38903).
PY - 2011/2
Y1 - 2011/2
N2 - A prominent population of innate CD8+ T cells develops in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3. These cells have the phenotype and function of memory CD8+ T cells, without previous exposure to antigen. Surprisingly, the cytokine IL-4 plays a key role in their development. As this developmental mechanism was discovered, it came to light that innate CD8+ T cells exist also in normal mice and in humans. In this review, we discuss how these cells develop, compare and contrast them to other CD8 memory cells, and discuss their potential physiological relevance.
AB - A prominent population of innate CD8+ T cells develops in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3. These cells have the phenotype and function of memory CD8+ T cells, without previous exposure to antigen. Surprisingly, the cytokine IL-4 plays a key role in their development. As this developmental mechanism was discovered, it came to light that innate CD8+ T cells exist also in normal mice and in humans. In this review, we discuss how these cells develop, compare and contrast them to other CD8 memory cells, and discuss their potential physiological relevance.
UR - http://www.scopus.com/inward/record.url?scp=79751529368&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79751529368&partnerID=8YFLogxK
U2 - 10.1016/j.it.2010.12.004
DO - 10.1016/j.it.2010.12.004
M3 - Review article
C2 - 21288770
AN - SCOPUS:79751529368
SN - 1471-4906
VL - 32
SP - 50
EP - 56
JO - Trends in Immunology
JF - Trends in Immunology
IS - 2
ER -