An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

Lu Chen; Caitlin M. Roake; Adam Freund; Pedro J. Batista; Siqi Tian; Yi A. Yin; Chandresh R. Gajera; Shengda Lin; Byron Lee; Matthew F. Pech; Andrew S. Venteicher; Rhiju Das; Howard Y. Chang; Steven E. Artandi

doi:10.1016/j.cell.2018.04.039

An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

Lu Chen, Caitlin M. Roake, Adam Freund, Pedro J. Batista, Siqi Tian, Yi A. Yin, Chandresh R. Gajera, Shengda Lin, Byron Lee, Matthew F. Pech, Andrew S. Venteicher, Rhiju Das, Howard Y. Chang, Steven E. Artandi

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

The holoenzyme protein TCAB1 stimulates telomerase activity by shaping the conformation of a telomerase RNA activity switch.

Original language	English (US)
Pages (from-to)	218-230.e13
Journal	Cell
Volume	174
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2018.04.039
State	Published - Jun 28 2018
Externally published	Yes

Bibliographical note

Funding Information:
We are grateful to members of the Artandi laboratory and to D. Herschlag for critical comments. This work was supported by NIH grants CA197563 and AG056575 (S.E.A.), GM122579 and GM102519 (R.D.), and HG004361 (H.Y.C.). C.M.R. was supported by MSTP Training Grant GM007365 and by a Gerald J. Lieberman Fellowship . L.C. was supported by a Stanford Cancer Institute 2018 Fellowship Award .

Keywords

CAB box
CR4/5
Cajal body
H/ACA RNP
RNA folding
TCAB1
dyskeratosis congenital
icSHAPE
telomerase
telomere

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1",

abstract = "The holoenzyme protein TCAB1 stimulates telomerase activity by shaping the conformation of a telomerase RNA activity switch.",

keywords = "CAB box, CR4/5, Cajal body, H/ACA RNP, RNA folding, TCAB1, dyskeratosis congenital, icSHAPE, telomerase, telomere",

author = "Lu Chen and Roake, {Caitlin M.} and Adam Freund and Batista, {Pedro J.} and Siqi Tian and Yin, {Yi A.} and Gajera, {Chandresh R.} and Shengda Lin and Byron Lee and Pech, {Matthew F.} and Venteicher, {Andrew S.} and Rhiju Das and Chang, {Howard Y.} and Artandi, {Steven E.}",

note = "Funding Information: We are grateful to members of the Artandi laboratory and to D. Herschlag for critical comments. This work was supported by NIH grants CA197563 and AG056575 (S.E.A.), GM122579 and GM102519 (R.D.), and HG004361 (H.Y.C.). C.M.R. was supported by MSTP Training Grant GM007365 and by a Gerald J. Lieberman Fellowship . L.C. was supported by a Stanford Cancer Institute 2018 Fellowship Award . ",

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AU - Chen, Lu

AU - Roake, Caitlin M.

AU - Freund, Adam

AU - Batista, Pedro J.

AU - Tian, Siqi

AU - Yin, Yi A.

AU - Gajera, Chandresh R.

AU - Lin, Shengda

AU - Lee, Byron

AU - Pech, Matthew F.

AU - Venteicher, Andrew S.

AU - Das, Rhiju

AU - Chang, Howard Y.

AU - Artandi, Steven E.

N1 - Funding Information: We are grateful to members of the Artandi laboratory and to D. Herschlag for critical comments. This work was supported by NIH grants CA197563 and AG056575 (S.E.A.), GM122579 and GM102519 (R.D.), and HG004361 (H.Y.C.). C.M.R. was supported by MSTP Training Grant GM007365 and by a Gerald J. Lieberman Fellowship . L.C. was supported by a Stanford Cancer Institute 2018 Fellowship Award .

PY - 2018/6/28

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N2 - The holoenzyme protein TCAB1 stimulates telomerase activity by shaping the conformation of a telomerase RNA activity switch.

AB - The holoenzyme protein TCAB1 stimulates telomerase activity by shaping the conformation of a telomerase RNA activity switch.

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KW - Cajal body

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KW - dyskeratosis congenital

KW - icSHAPE

KW - telomerase

KW - telomere

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An Activity Switch in Human Telomerase Based on RNA Conformation and Shaped by TCAB1

Abstract

Bibliographical note

Keywords

UN SDGs

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