TY - JOUR
T1 - An anthraquinone with potent quinone reductase-inducing activity and other constituents of the fruits of Morinda citrifolia (Noni)
AU - Pawlus, Alison D.
AU - Su, Bao Ning
AU - Keller, William J.
AU - Kinghorn, A. Douglas
PY - 2005/12
Y1 - 2005/12
N2 - Morinda citrifolia, commonly known as noni, has ȧ long history of utilization throughout much of tropical Polynesia and is considered to be the second most important medicinal plant in the Hawaiian Islands. Recently, the use of noni as a dietary supplement in the United States has greatly increased. Bioassay-guided fractionation of a dichloromethane-soluble partition of a MeOH extract of noni fruits has led to the isolation of an extremely potent quinone reductase inducer, 2-methoxy-1,3,6-trihydroxyanthraquinone (1). This new anthraquinone (1) was nearly 40 times more potent than a positive control, L-sulforaphane. Furthermore, compound 1 demonstrated no discernible cytotoxicity at the highest dose tested. In addition to compound 1, 11 known compounds were also isolated and identified in the present investigation. This is the first report of the isolation of anthraquinones from noni fruits.
AB - Morinda citrifolia, commonly known as noni, has ȧ long history of utilization throughout much of tropical Polynesia and is considered to be the second most important medicinal plant in the Hawaiian Islands. Recently, the use of noni as a dietary supplement in the United States has greatly increased. Bioassay-guided fractionation of a dichloromethane-soluble partition of a MeOH extract of noni fruits has led to the isolation of an extremely potent quinone reductase inducer, 2-methoxy-1,3,6-trihydroxyanthraquinone (1). This new anthraquinone (1) was nearly 40 times more potent than a positive control, L-sulforaphane. Furthermore, compound 1 demonstrated no discernible cytotoxicity at the highest dose tested. In addition to compound 1, 11 known compounds were also isolated and identified in the present investigation. This is the first report of the isolation of anthraquinones from noni fruits.
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U2 - 10.1021/np050383k
DO - 10.1021/np050383k
M3 - Article
C2 - 16378361
AN - SCOPUS:30544455292
SN - 0163-3864
VL - 68
SP - 1720
EP - 1722
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 12
ER -