An efficient synthesis of RNA containing GS-441524: The nucleoside precursor of remdesivir

Ramkumar Moorthy; Samantha A. Kennelly; Deborah J. Rodriguez; Daniel A. Harki

doi:10.1039/d1ra06589k

An efficient synthesis of RNA containing GS-441524: The nucleoside precursor of remdesivir

Ramkumar Moorthy, Samantha A. Kennelly, Deborah J. Rodriguez, Daniel A. Harki

Medicinal Chemistry

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2 Scopus citations

Abstract

Remdesivir is an antiviral nucleoside phosphoramidate with activity against multiple viruses, including SARS-CoV-2. To enable studies of viral polymerases with RNA containing remdesivir, we report an efficient synthesis of a phosphoramidite of GS-441524, the nucleoside precursor of remdesivir, and its incorporation into RNA using automated solid-phase RNA synthesis.

Original language	English (US)
Pages (from-to)	31373-31376
Number of pages	4
Journal	RSC Advances
Volume	11
Issue number	50
DOIs	https://doi.org/10.1039/d1ra06589k
State	Published - Sep 14 2021

Bibliographical note

Funding Information:
We gratefully acknowledge the NIH (P01-CA234228) and the University of Minnesota for nancial support. Mass spectrometry was performed at the University of Minnesota Masonic Cancer Center Analytical Biochemistry Core Facility, which is supported by the NIH (P30-CA77598).

Publisher Copyright:
© 2021 The Royal Society of Chemistry.

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AU - Harki, Daniel A.

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An efficient synthesis of RNA containing GS-441524: The nucleoside precursor of remdesivir

Abstract

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