Abstract
The particle structure of human T-cell leukemia virus type 1 (HTLV-1) is poorly characterized. Here, we have used cryo-electron tomography to analyze HTLV-1 particle morphology. Particles produced from MT-2 cells were polymorphic, roughly spherical, and varied in size. Capsid cores, when present, were typically poorly defined polyhedral structures with at least one curved region contacting the inner face of the viral membrane. Most of the particles observed lacked a defined capsid core, which likely impacts HTLV-1 particle infectivity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2430-2435 |
| Number of pages | 6 |
| Journal | Journal of virology |
| Volume | 89 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2015 |
Bibliographical note
Publisher Copyright:© 2015, American Society for Microbiology.