Antibody-Mediated Graft Rejection in Nonhuman Primate Models: Comparison of Sensitized Allotransplant and Xenotransplant Rejection

Stuart J. Knechtle; Jean Kwun; Brendon Lovasik; Alton B. Farris; A. Joseph Tector; Andrew B. Adams

doi:10.1007/978-3-030-49127-7_9

Antibody-Mediated Graft Rejection in Nonhuman Primate Models: Comparison of Sensitized Allotransplant and Xenotransplant Rejection

Stuart J. Knechtle, Jean Kwun, Brendon Lovasik, Alton B. Farris, A. Joseph Tector, Andrew B. Adams

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Antibody-mediated rejection (AMR) is a barrier to successful long-term xenograft survival. We compared AMR in kidney xenotransplantation to sensitized kidney allotransplantation in a nonhuman primate model. With conventional CNI-based immunosuppressive maintenance, both groups showed limited graft survival with strong antibody-mediated rejection features, such as interstitial hemorrhage, thrombotic microangiopathy, peritubular capillaritis, and glomerulitis, without T-cell-mediated rejection. The strong similarity between sensitized allo- and unsensitized xeno-rejection suggests a possible common mechanism of rejection in xeno and sensitized allotransplantation. Further investigation is warranted to evaluate desensitization strategies that have shown efficacy in an allosensitized setting to determine if they may apply as well to xenotransplantation. It would also be important to determine whether allosensitized hosts are also primed to xeno-AMR and, vice versa, whether xenotransplantation primes the immune response to allo-AMR.

Original language	English (US)
Title of host publication	Clinical Xenotransplantation
Subtitle of host publication	Pathways and Progress in the Transplantation of Organs and Tissues Between Species
Publisher	Springer International Publishing
Pages	157-164
Number of pages	8
ISBN (Electronic)	9783030491277
ISBN (Print)	9783030491260
DOIs	https://doi.org/10.1007/978-3-030-49127-7_9
State	Published - Jan 1 2020
Externally published	Yes

Bibliographical note

Publisher Copyright:
© Springer Nature Switzerland AG 2020. © Springer Nature Switzerland AG 2020.

Keywords

Allotransplantation
Antibody-mediated rejection
Donor-specific antibody
Nonhuman primates
Pig
Xenotransplantation

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Knechtle, S. J., Kwun, J., Lovasik, B., Farris, A. B., Tector, A. J., & Adams, A. B. (2020). Antibody-Mediated Graft Rejection in Nonhuman Primate Models: Comparison of Sensitized Allotransplant and Xenotransplant Rejection. In Clinical Xenotransplantation: Pathways and Progress in the Transplantation of Organs and Tissues Between Species (pp. 157-164). Springer International Publishing. https://doi.org/10.1007/978-3-030-49127-7_9

Antibody-Mediated Graft Rejection in Nonhuman Primate Models: Comparison of Sensitized Allotransplant and Xenotransplant Rejection. / Knechtle, Stuart J.; Kwun, Jean; Lovasik, Brendon et al.
Clinical Xenotransplantation: Pathways and Progress in the Transplantation of Organs and Tissues Between Species. Springer International Publishing, 2020. p. 157-164.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Knechtle, SJ, Kwun, J, Lovasik, B, Farris, AB, Tector, AJ & Adams, AB 2020, Antibody-Mediated Graft Rejection in Nonhuman Primate Models: Comparison of Sensitized Allotransplant and Xenotransplant Rejection. in Clinical Xenotransplantation: Pathways and Progress in the Transplantation of Organs and Tissues Between Species. Springer International Publishing, pp. 157-164. https://doi.org/10.1007/978-3-030-49127-7_9

Knechtle SJ, Kwun J, Lovasik B, Farris AB, Tector AJ, Adams AB. Antibody-Mediated Graft Rejection in Nonhuman Primate Models: Comparison of Sensitized Allotransplant and Xenotransplant Rejection. In Clinical Xenotransplantation: Pathways and Progress in the Transplantation of Organs and Tissues Between Species. Springer International Publishing. 2020. p. 157-164 doi: 10.1007/978-3-030-49127-7_9

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abstract = "Antibody-mediated rejection (AMR) is a barrier to successful long-term xenograft survival. We compared AMR in kidney xenotransplantation to sensitized kidney allotransplantation in a nonhuman primate model. With conventional CNI-based immunosuppressive maintenance, both groups showed limited graft survival with strong antibody-mediated rejection features, such as interstitial hemorrhage, thrombotic microangiopathy, peritubular capillaritis, and glomerulitis, without T-cell-mediated rejection. The strong similarity between sensitized allo- and unsensitized xeno-rejection suggests a possible common mechanism of rejection in xeno and sensitized allotransplantation. Further investigation is warranted to evaluate desensitization strategies that have shown efficacy in an allosensitized setting to determine if they may apply as well to xenotransplantation. It would also be important to determine whether allosensitized hosts are also primed to xeno-AMR and, vice versa, whether xenotransplantation primes the immune response to allo-AMR.",

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Antibody-Mediated Graft Rejection in Nonhuman Primate Models: Comparison of Sensitized Allotransplant and Xenotransplant Rejection

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