Antisense oligonucleotide treatment reveals a physiologically relevant role for adrenomedullin gene products in sodium intake

Willis K. Samson; Ann M. Bode; Tonya C. Murphy; Zachary T. Resch

doi:10.1016/S0006-8993(98)01268-2

Antisense oligonucleotide treatment reveals a physiologically relevant role for adrenomedullin gene products in sodium intake

Willis K. Samson, Ann M. Bode, Tonya C. Murphy, Zachary T. Resch

Hormel Institute

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Adrenomedullin (AM), a potent hypotensive peptide, is produced in numerous tissues including adrenal gland, kidney, brain and pituitary gland, where it acts to modify sodium homeostasis. Central AM administration dose- dependently inhibits sodium appetite. AM antisense oligonucleotide treatment significantly lowered peptide content in the hypothalamic paraventricular (PVN) nucleus and exaggerated the consumption of sodium. These results support a physiologic role for adrenomedullin gene products in the central regulation of sodium homeostasis.

Original language	English (US)
Pages (from-to)	164-167
Number of pages	4
Journal	Brain Research
Volume	818
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(98)01268-2
State	Published - Feb 6 1999

Bibliographical note

Funding Information:
This work was supported by a grant from the Max Baer Heart Fund, Dakota Aerie of the Fraternal Order of Eagles.

Keywords

Adrenomedullin
Antisense
Salt appetite

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title = "Antisense oligonucleotide treatment reveals a physiologically relevant role for adrenomedullin gene products in sodium intake",

abstract = "Adrenomedullin (AM), a potent hypotensive peptide, is produced in numerous tissues including adrenal gland, kidney, brain and pituitary gland, where it acts to modify sodium homeostasis. Central AM administration dose- dependently inhibits sodium appetite. AM antisense oligonucleotide treatment significantly lowered peptide content in the hypothalamic paraventricular (PVN) nucleus and exaggerated the consumption of sodium. These results support a physiologic role for adrenomedullin gene products in the central regulation of sodium homeostasis.",

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AU - Murphy, Tonya C.

AU - Resch, Zachary T.

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N2 - Adrenomedullin (AM), a potent hypotensive peptide, is produced in numerous tissues including adrenal gland, kidney, brain and pituitary gland, where it acts to modify sodium homeostasis. Central AM administration dose- dependently inhibits sodium appetite. AM antisense oligonucleotide treatment significantly lowered peptide content in the hypothalamic paraventricular (PVN) nucleus and exaggerated the consumption of sodium. These results support a physiologic role for adrenomedullin gene products in the central regulation of sodium homeostasis.

AB - Adrenomedullin (AM), a potent hypotensive peptide, is produced in numerous tissues including adrenal gland, kidney, brain and pituitary gland, where it acts to modify sodium homeostasis. Central AM administration dose- dependently inhibits sodium appetite. AM antisense oligonucleotide treatment significantly lowered peptide content in the hypothalamic paraventricular (PVN) nucleus and exaggerated the consumption of sodium. These results support a physiologic role for adrenomedullin gene products in the central regulation of sodium homeostasis.

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KW - Salt appetite

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Antisense oligonucleotide treatment reveals a physiologically relevant role for adrenomedullin gene products in sodium intake

Abstract

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Keywords

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