ASSESSMENT OF CONTRACTILE FORCES OF SWINE SKELETAL MUSCLE FOLLOWING IRREVERSIBLE ELECTROPORATION THERAPY

David A. Ramirez; Paul A. Iaizzo

doi:10.1115/DMD2022-1070

ASSESSMENT OF CONTRACTILE FORCES OF SWINE SKELETAL MUSCLE FOLLOWING IRREVERSIBLE ELECTROPORATION THERAPY

David A. Ramirez, Paul A. Iaizzo

Surgery

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Irreversible electroporation has regained a new popularity as a robust and effective ablation modality. One concern however that remains is the optimization of the several parameters to further implement the technology in medical therapies; one of the most important effects is the mitigation of muscle stimulation. Here we present the induced contractile force on swine skeletal muscle after delivery of irreversible electroporation therapies. We aim to evaluate two differing waveforms, the classic irreversible electroporation, IRE, with monophasic DC pulses of 100µs pulse widths, and a waveform of High Frequency Irreversible Electroporation, HFIRE. We observed that the short duration pulses of HFIRE, biphasic 2µs pulse width, effectively induced no contractile forces on skeletal muscle. In contrast IRE induced large contractions.

Original language	English (US)
Title of host publication	Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022
Publisher	American Society of Mechanical Engineers
ISBN (Electronic)	9780791885710
DOIs	https://doi.org/10.1115/DMD2022-1070
State	Published - 2022
Event	2022 Design of Medical Devices Conference, DMD 2022 - Minneapolis, Virtual, United States Duration: Apr 11 2022 → Apr 14 2022

Publication series

Name	Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022

Conference

Conference	2022 Design of Medical Devices Conference, DMD 2022
Country/Territory	United States
City	Minneapolis, Virtual
Period	4/11/22 → 4/14/22

Bibliographical note

Publisher Copyright:
© 2022 by ASME

Keywords

Ablation
HFIRE
IRE
Irreversible Electroporation
Pulsed Field Ablation

Access

10.1115/DMD2022-1070

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Cite this

Ramirez, D. A., & Iaizzo, P. A. (2022). ASSESSMENT OF CONTRACTILE FORCES OF SWINE SKELETAL MUSCLE FOLLOWING IRREVERSIBLE ELECTROPORATION THERAPY. In Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022 Article V001T01A007 (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022). American Society of Mechanical Engineers. https://doi.org/10.1115/DMD2022-1070

ASSESSMENT OF CONTRACTILE FORCES OF SWINE SKELETAL MUSCLE FOLLOWING IRREVERSIBLE ELECTROPORATION THERAPY. / Ramirez, David A.; Iaizzo, Paul A.
Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022. American Society of Mechanical Engineers, 2022. V001T01A007 (Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Ramirez, DA & Iaizzo, PA 2022, ASSESSMENT OF CONTRACTILE FORCES OF SWINE SKELETAL MUSCLE FOLLOWING IRREVERSIBLE ELECTROPORATION THERAPY. in Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022., V001T01A007, Proceedings of the 2022 Design of Medical Devices Conference, DMD 2022, American Society of Mechanical Engineers, 2022 Design of Medical Devices Conference, DMD 2022, Minneapolis, Virtual, United States, 4/11/22. https://doi.org/10.1115/DMD2022-1070

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abstract = "Irreversible electroporation has regained a new popularity as a robust and effective ablation modality. One concern however that remains is the optimization of the several parameters to further implement the technology in medical therapies; one of the most important effects is the mitigation of muscle stimulation. Here we present the induced contractile force on swine skeletal muscle after delivery of irreversible electroporation therapies. We aim to evaluate two differing waveforms, the classic irreversible electroporation, IRE, with monophasic DC pulses of 100µs pulse widths, and a waveform of High Frequency Irreversible Electroporation, HFIRE. We observed that the short duration pulses of HFIRE, biphasic 2µs pulse width, effectively induced no contractile forces on skeletal muscle. In contrast IRE induced large contractions.",

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ASSESSMENT OF CONTRACTILE FORCES OF SWINE SKELETAL MUSCLE FOLLOWING IRREVERSIBLE ELECTROPORATION THERAPY

Abstract

Publication series

Conference

Bibliographical note

Keywords

Access

OpenUrl availability

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