TY - JOUR
T1 - Association between dementia and elevated TSH
T2 - A community-based study
AU - Ganguli, Mary
AU - Burmeister, Lynn A.
AU - Seaberg, Eric C.
AU - Belle, Steven
AU - DeKosky, Steven T.
PY - 1996/10/15
Y1 - 1996/10/15
N2 - We report on 194 individuals (96 men and 98 women), aged 65 and over, who had dementia assessments and basal TSH measurements as part of an ongoing epidemiological study of dementing disorders in a larger population. Dementia was diagnosed according to DSM-III-R and measured by the Clinical Dementia Rating scale; CDR scores of 0, 0.5, and ≤ 1, represent individuals with no dementia (n = 122), possible dementia (n = 29), and definite dementia (n = 43), respectively. The odds ratio for the association of elevated TSH with definite dementia (CDR ≤ 1) was 3.8 (95% confidence interval = 1.6, 9.1) and with possible and/or definite dementia (CDR ≤ 0.5) was 3.8 (95% confidence interval = 1.6, 9.2), after adjusting for the effects of age, gender, and level of education. This is the first community-based study to report an association between TSH elevation and dementia. Our findings are consistent with recent evidence that subclinical hypothyroidism is associated with cognitive impairment, and that thyroidal state may influence cerebral metabolism.
AB - We report on 194 individuals (96 men and 98 women), aged 65 and over, who had dementia assessments and basal TSH measurements as part of an ongoing epidemiological study of dementing disorders in a larger population. Dementia was diagnosed according to DSM-III-R and measured by the Clinical Dementia Rating scale; CDR scores of 0, 0.5, and ≤ 1, represent individuals with no dementia (n = 122), possible dementia (n = 29), and definite dementia (n = 43), respectively. The odds ratio for the association of elevated TSH with definite dementia (CDR ≤ 1) was 3.8 (95% confidence interval = 1.6, 9.1) and with possible and/or definite dementia (CDR ≤ 0.5) was 3.8 (95% confidence interval = 1.6, 9.2), after adjusting for the effects of age, gender, and level of education. This is the first community-based study to report an association between TSH elevation and dementia. Our findings are consistent with recent evidence that subclinical hypothyroidism is associated with cognitive impairment, and that thyroidal state may influence cerebral metabolism.
KW - aging
KW - cognition
KW - dementia
KW - epidemiology
KW - thyroid
KW - thyrotropin
UR - http://www.scopus.com/inward/record.url?scp=0030588113&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030588113&partnerID=8YFLogxK
U2 - 10.1016/0006-3223(95)00489-0
DO - 10.1016/0006-3223(95)00489-0
M3 - Article
C2 - 8894063
AN - SCOPUS:0030588113
SN - 0006-3223
VL - 40
SP - 714
EP - 725
JO - Biological psychiatry
JF - Biological psychiatry
IS - 8
ER -