Association between the amygdala and nucleus of the solitary tract in μ-opioid induced feeding in the rat

Silvia Q. Giraudo; Catherine M Kotz; Charles J Billington; Allen S Levine

doi:10.1016/S0006-8993(98)00602-7

Association between the amygdala and nucleus of the solitary tract in μ-opioid induced feeding in the rat

Silvia Q. Giraudo, Catherine M Kotz, Charles J Billington, Allen S Levine

Research output: Contribution to journal › Article › peer-review

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Abstract

The central nucleus of the amygdala (CNA) and the nucleus of the solitary tract (NTS) are important in the regulation of ingestive behavior. We evaluated whether opioid-opioid signaling between the CNA and rostral NTS (rNTS) affect feeding behavior. To test this, rats were doubly cannulated with one cannula placed in the rNTS and one cannula in the CNA, allowing for co-administration of an opioid agonist into one site and an opioid antagonist into the other. Tyr-D-Ala-Gly-(me) Phe-Gly-ol (DAMGO) (2 nmol) injected into the CNA (CNA DAMGO) increased feeding more than two-fold compared to the vehicle-injected rats. This increase in food intake was blocked when doses of 26.5 and 79 nmol of naltrexone (NTX) were injected into the rNTS. In the reverse situation, rNTS DAMGO increased food intake above control levels, and CNA NTX blocked DAMGO-induced feeding when administrated in doses of 26.5 and 79 nmol. This suggests that a bi-directional opioid-opioid signaling pathway exists between the CNA and the rNTS which influences feeding via μ-opioid receptors.

Original language	English (US)
Pages (from-to)	184-188
Number of pages	5
Journal	Brain Research
Volume	802
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(98)00602-7
State	Published - Sep 17 1998

Bibliographical note

Funding Information:
This research was supported by the General Research Funds of the Veterans Administration Medical Center, the National Institute of Diabetes and Digestive and Kidney Diseases Grant DK 50456 and by the National Institute of Drug Abuse Grant DA-03999. We thank Jim Pomonis and Martha Grace for their technical assistance.

Keywords

Central nucleus of the amygdala
DAMGO
Food intake
Naltrexone
Nucleus of the solitary tract

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title = "Association between the amygdala and nucleus of the solitary tract in μ-opioid induced feeding in the rat",

abstract = "The central nucleus of the amygdala (CNA) and the nucleus of the solitary tract (NTS) are important in the regulation of ingestive behavior. We evaluated whether opioid-opioid signaling between the CNA and rostral NTS (rNTS) affect feeding behavior. To test this, rats were doubly cannulated with one cannula placed in the rNTS and one cannula in the CNA, allowing for co-administration of an opioid agonist into one site and an opioid antagonist into the other. Tyr-D-Ala-Gly-(me) Phe-Gly-ol (DAMGO) (2 nmol) injected into the CNA (CNA DAMGO) increased feeding more than two-fold compared to the vehicle-injected rats. This increase in food intake was blocked when doses of 26.5 and 79 nmol of naltrexone (NTX) were injected into the rNTS. In the reverse situation, rNTS DAMGO increased food intake above control levels, and CNA NTX blocked DAMGO-induced feeding when administrated in doses of 26.5 and 79 nmol. This suggests that a bi-directional opioid-opioid signaling pathway exists between the CNA and the rNTS which influences feeding via μ-opioid receptors.",

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Association between the amygdala and nucleus of the solitary tract in μ-opioid induced feeding in the rat

Abstract

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Keywords

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