Associations between GrimAge acceleration and pulmonary function in the Coronary Artery Risk Development in Young Adults (CARDIA) study

Brian T. Joyce; Xuefen Chen; Tao Gao; Yinan Zheng; Drew R. Nannini; Lei Liu; Benjamin E. Henkle; Ravi Kalhan; George Washko; Ken M. Kunisaki; Bharat Thyagarajan; Douglas E. Vaughan; Myron Gross; David R. Jacobs; Donald Lloyd-Jones; Lifang Hou

doi:10.2217/epi-2023-0164

Associations between GrimAge acceleration and pulmonary function in the Coronary Artery Risk Development in Young Adults (CARDIA) study

Brian T. Joyce, Xuefen Chen, Tao Gao, Yinan Zheng, Drew R. Nannini, Lei Liu, Benjamin E. Henkle, Ravi Kalhan, George Washko, Ken M. Kunisaki, Bharat Thyagarajan, Douglas E. Vaughan, Myron Gross, David R. Jacobs, Donald Lloyd-Jones, Lifang Hou

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Abstract

Background: The objective of this research was to determine whether pulmonary function is associated with epigenetic aging (GrimAge) and whether GrimAge predicts emphysema. Methods: This prospective study examined 1042 participants enrolled as part of a community-based longitudinal cohort. The cross-sectional associations between pulmonary function and GrimAge, measured at study year (Y) 20 (participant ages 40-45 years), and prospective associations with emphysema at Y25 were examined. Results: At Y20, forced expiratory volume in 1 s (FEV₁) and FEV₁/forced vital capacity (FVC) were negatively associated with GrimAge; for Y0-Y10 cumulative measures, only the FEV₁/FVC ratio was associated with GrimAge at Y15 and Y20. Emphysema at Y25 was associated with GrimAge at Y15 and Y20. Conclusion: Pulmonary function was associated with GrimAge during early and mid-life; GrimAge partially mediated the association between pulmonary function and emphysema.

Original language	English (US)
Pages (from-to)	693-703
Number of pages	11
Journal	Epigenomics
Volume	15
Issue number	13
DOIs	https://doi.org/10.2217/epi-2023-0164
State	Published - Jul 1 2023

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Publisher Copyright:
© 2023 Future Medicine Ltd.

Keywords

DNA methylation age
aging
emphysema
lung function
methylation

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Intramural
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

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Joyce, B. T., Chen, X., Gao, T., Zheng, Y., Nannini, D. R., Liu, L., Henkle, B. E., Kalhan, R., Washko, G., Kunisaki, K. M., Thyagarajan, B., Vaughan, D. E., Gross, M., Jacobs, D. R., Lloyd-Jones, D., & Hou, L. (2023). Associations between GrimAge acceleration and pulmonary function in the Coronary Artery Risk Development in Young Adults (CARDIA) study. Epigenomics, 15(13), 693-703. https://doi.org/10.2217/epi-2023-0164

Joyce, BT, Chen, X, Gao, T, Zheng, Y, Nannini, DR, Liu, L, Henkle, BE, Kalhan, R, Washko, G, Kunisaki, KM , Thyagarajan, B, Vaughan, DE, Gross, M , Jacobs, DR, Lloyd-Jones, D & Hou, L 2023, 'Associations between GrimAge acceleration and pulmonary function in the Coronary Artery Risk Development in Young Adults (CARDIA) study', Epigenomics, vol. 15, no. 13, pp. 693-703. https://doi.org/10.2217/epi-2023-0164

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abstract = "Background: The objective of this research was to determine whether pulmonary function is associated with epigenetic aging (GrimAge) and whether GrimAge predicts emphysema. Methods: This prospective study examined 1042 participants enrolled as part of a community-based longitudinal cohort. The cross-sectional associations between pulmonary function and GrimAge, measured at study year (Y) 20 (participant ages 40-45 years), and prospective associations with emphysema at Y25 were examined. Results: At Y20, forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) were negatively associated with GrimAge; for Y0-Y10 cumulative measures, only the FEV1/FVC ratio was associated with GrimAge at Y15 and Y20. Emphysema at Y25 was associated with GrimAge at Y15 and Y20. Conclusion: Pulmonary function was associated with GrimAge during early and mid-life; GrimAge partially mediated the association between pulmonary function and emphysema.",

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author = "Joyce, {Brian T.} and Xuefen Chen and Tao Gao and Yinan Zheng and Nannini, {Drew R.} and Lei Liu and Henkle, {Benjamin E.} and Ravi Kalhan and George Washko and Kunisaki, {Ken M.} and Bharat Thyagarajan and Vaughan, {Douglas E.} and Myron Gross and Jacobs, {David R.} and Donald Lloyd-Jones and Lifang Hou",

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AU - Chen, Xuefen

AU - Gao, Tao

AU - Zheng, Yinan

AU - Nannini, Drew R.

AU - Liu, Lei

AU - Henkle, Benjamin E.

AU - Kalhan, Ravi

AU - Washko, George

AU - Kunisaki, Ken M.

AU - Thyagarajan, Bharat

AU - Vaughan, Douglas E.

AU - Gross, Myron

AU - Jacobs, David R.

AU - Lloyd-Jones, Donald

AU - Hou, Lifang

PY - 2023/7/1

Y1 - 2023/7/1

N2 - Background: The objective of this research was to determine whether pulmonary function is associated with epigenetic aging (GrimAge) and whether GrimAge predicts emphysema. Methods: This prospective study examined 1042 participants enrolled as part of a community-based longitudinal cohort. The cross-sectional associations between pulmonary function and GrimAge, measured at study year (Y) 20 (participant ages 40-45 years), and prospective associations with emphysema at Y25 were examined. Results: At Y20, forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) were negatively associated with GrimAge; for Y0-Y10 cumulative measures, only the FEV1/FVC ratio was associated with GrimAge at Y15 and Y20. Emphysema at Y25 was associated with GrimAge at Y15 and Y20. Conclusion: Pulmonary function was associated with GrimAge during early and mid-life; GrimAge partially mediated the association between pulmonary function and emphysema.

AB - Background: The objective of this research was to determine whether pulmonary function is associated with epigenetic aging (GrimAge) and whether GrimAge predicts emphysema. Methods: This prospective study examined 1042 participants enrolled as part of a community-based longitudinal cohort. The cross-sectional associations between pulmonary function and GrimAge, measured at study year (Y) 20 (participant ages 40-45 years), and prospective associations with emphysema at Y25 were examined. Results: At Y20, forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) were negatively associated with GrimAge; for Y0-Y10 cumulative measures, only the FEV1/FVC ratio was associated with GrimAge at Y15 and Y20. Emphysema at Y25 was associated with GrimAge at Y15 and Y20. Conclusion: Pulmonary function was associated with GrimAge during early and mid-life; GrimAge partially mediated the association between pulmonary function and emphysema.

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KW - emphysema

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KW - methylation

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Associations between GrimAge acceleration and pulmonary function in the Coronary Artery Risk Development in Young Adults (CARDIA) study

Abstract

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