Associations between lean mass and leptin in men with chronic spinal cord injury: Results from the FRASCI-muscle study

Andrew J. Park; Ricardo A. Battaglino; Nguyen M.H. Nguyen; Leslie R. Morse

doi:10.1371/journal.pone.0198969

Associations between lean mass and leptin in men with chronic spinal cord injury: Results from the FRASCI-muscle study

Andrew J. Park, Ricardo A. Battaglino, Nguyen M.H. Nguyen, Leslie R. Morse

Medicine - Cardiology Division

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Leptin is an adipo-myokine that regulates appetite and energy expenditure by a neuroendocrine feedback loop. Leptin levels are positively correlated with BMI in the spinal cord injury population and leptin levels are greater in individuals with spinal cord injury compared to uninjured controls. Leptin is produced in multiple tissues, including fat, bone, and skeletal muscle and is a putative biomarker of sedentary behavior in older adults. We assessed body composition leptin, adiponectin, and IL-6 levels in 205 men with chronic spinal cord injury. We found no association between age, injury duration, injury level, injury completeness, or walking status and leptin. There was a significant positive association between lean mass and leptin in men with SCI that was independent of fat. Adjusting for body composition, leptin levels were positively associated with IL-6 and negatively associated with adiponectin levels. When considering men with SCI and sarcopenic obesity, only fat mass remained positively associated with leptin. We found no association between IL-6, adiponectin, or lean mass and leptin in the sarcopenic obesity group. Our findings suggest that lean mass is an under recognized, but substantial, source of circulating leptin. Furthermore, SCI-related sarcopenic obesity may result in dysregulated adipo-myokine metabolism with local and systemic physiologic effects.

Original language	English (US)
Article number	e0198969
Journal	PloS one
Volume	13
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0198969
State	Published - Jun 2018

Bibliographical note

Funding Information:
Funded by National Institute of Arthritis and Musculoskeletal and Skin Diseases [1R01AR059270-01] https://www.niams.nih.gov/ LRM and RAB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript Department of Health and Human Services [90SI5015-01-00] https://www.hhs.gov/ LRM and RAB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2018 Park et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1371/journal.pone.0198969

OpenUrl availability

Full text

Cite this

@article{08766b95eb49428684d32f69db284d4a,

title = "Associations between lean mass and leptin in men with chronic spinal cord injury: Results from the FRASCI-muscle study",

abstract = "Leptin is an adipo-myokine that regulates appetite and energy expenditure by a neuroendocrine feedback loop. Leptin levels are positively correlated with BMI in the spinal cord injury population and leptin levels are greater in individuals with spinal cord injury compared to uninjured controls. Leptin is produced in multiple tissues, including fat, bone, and skeletal muscle and is a putative biomarker of sedentary behavior in older adults. We assessed body composition leptin, adiponectin, and IL-6 levels in 205 men with chronic spinal cord injury. We found no association between age, injury duration, injury level, injury completeness, or walking status and leptin. There was a significant positive association between lean mass and leptin in men with SCI that was independent of fat. Adjusting for body composition, leptin levels were positively associated with IL-6 and negatively associated with adiponectin levels. When considering men with SCI and sarcopenic obesity, only fat mass remained positively associated with leptin. We found no association between IL-6, adiponectin, or lean mass and leptin in the sarcopenic obesity group. Our findings suggest that lean mass is an under recognized, but substantial, source of circulating leptin. Furthermore, SCI-related sarcopenic obesity may result in dysregulated adipo-myokine metabolism with local and systemic physiologic effects.",

author = "Park, {Andrew J.} and Battaglino, {Ricardo A.} and Nguyen, {Nguyen M.H.} and Morse, {Leslie R.}",

note = "Funding Information: Funded by National Institute of Arthritis and Musculoskeletal and Skin Diseases [1R01AR059270-01] https://www.niams.nih.gov/ LRM and RAB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript Department of Health and Human Services [90SI5015-01-00] https://www.hhs.gov/ LRM and RAB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2018 Park et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",

year = "2018",

month = jun,

doi = "10.1371/journal.pone.0198969",

language = "English (US)",

volume = "13",

journal = "PloS one",

issn = "1932-6203",

publisher = "Public Library of Science",

number = "6",

}

TY - JOUR

T1 - Associations between lean mass and leptin in men with chronic spinal cord injury

T2 - Results from the FRASCI-muscle study

AU - Park, Andrew J.

AU - Battaglino, Ricardo A.

AU - Nguyen, Nguyen M.H.

AU - Morse, Leslie R.

N1 - Funding Information: Funded by National Institute of Arthritis and Musculoskeletal and Skin Diseases [1R01AR059270-01] https://www.niams.nih.gov/ LRM and RAB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript Department of Health and Human Services [90SI5015-01-00] https://www.hhs.gov/ LRM and RAB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2018 Park et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2018/6

Y1 - 2018/6

N2 - Leptin is an adipo-myokine that regulates appetite and energy expenditure by a neuroendocrine feedback loop. Leptin levels are positively correlated with BMI in the spinal cord injury population and leptin levels are greater in individuals with spinal cord injury compared to uninjured controls. Leptin is produced in multiple tissues, including fat, bone, and skeletal muscle and is a putative biomarker of sedentary behavior in older adults. We assessed body composition leptin, adiponectin, and IL-6 levels in 205 men with chronic spinal cord injury. We found no association between age, injury duration, injury level, injury completeness, or walking status and leptin. There was a significant positive association between lean mass and leptin in men with SCI that was independent of fat. Adjusting for body composition, leptin levels were positively associated with IL-6 and negatively associated with adiponectin levels. When considering men with SCI and sarcopenic obesity, only fat mass remained positively associated with leptin. We found no association between IL-6, adiponectin, or lean mass and leptin in the sarcopenic obesity group. Our findings suggest that lean mass is an under recognized, but substantial, source of circulating leptin. Furthermore, SCI-related sarcopenic obesity may result in dysregulated adipo-myokine metabolism with local and systemic physiologic effects.

AB - Leptin is an adipo-myokine that regulates appetite and energy expenditure by a neuroendocrine feedback loop. Leptin levels are positively correlated with BMI in the spinal cord injury population and leptin levels are greater in individuals with spinal cord injury compared to uninjured controls. Leptin is produced in multiple tissues, including fat, bone, and skeletal muscle and is a putative biomarker of sedentary behavior in older adults. We assessed body composition leptin, adiponectin, and IL-6 levels in 205 men with chronic spinal cord injury. We found no association between age, injury duration, injury level, injury completeness, or walking status and leptin. There was a significant positive association between lean mass and leptin in men with SCI that was independent of fat. Adjusting for body composition, leptin levels were positively associated with IL-6 and negatively associated with adiponectin levels. When considering men with SCI and sarcopenic obesity, only fat mass remained positively associated with leptin. We found no association between IL-6, adiponectin, or lean mass and leptin in the sarcopenic obesity group. Our findings suggest that lean mass is an under recognized, but substantial, source of circulating leptin. Furthermore, SCI-related sarcopenic obesity may result in dysregulated adipo-myokine metabolism with local and systemic physiologic effects.

UR - http://www.scopus.com/inward/record.url?scp=85049128867&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049128867&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0198969

DO - 10.1371/journal.pone.0198969

M3 - Article

C2 - 29949600

AN - SCOPUS:85049128867

SN - 1932-6203

VL - 13

JO - PloS one

JF - PloS one

IS - 6

M1 - e0198969

ER -

Associations between lean mass and leptin in men with chronic spinal cord injury: Results from the FRASCI-muscle study

Abstract

Bibliographical note

PubMed: MeSH publication types

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this