TY - JOUR
T1 - Associations of Binge Drinking With Vascular Brain Injury and Atrophy in Older American Indians
T2 - The Strong Heart Study
AU - Lewis, Jordan P.
AU - Suchy-Dicey, Astrid M.
AU - Noonan, Carolyn
AU - Blue Bird Jernigan, Valarie
AU - Umans, Jason G.
AU - Domoto-Reilly, Kimiko
AU - Buchwald, Dedra S.
AU - Manson, Spero M.
N1 - Publisher Copyright:
© The Author(s) 2021.
PY - 2021/8
Y1 - 2021/8
N2 - Objectives: American Indians (AIs) generally consume less alcohol than the US general population; however, the prevalence of alcohol use disorder is higher. This is the first large cohort study to examine binge drinking as a risk factor for vascular brain injury (VBI). Methods: We used linear and Poisson regression to examine the association of self-reported binge drinking with VBI, measured via magnetic resonance imaging (MRI), in 817 older AIs who participated in the Strong Heart and Cerebrovascular Disease and Its Consequences in American Indians studies. Results: Any binge drinking at multiple time-points was associated with increased sulcal (β = 0.360, 95% CI [0.079, 0.641]) and ventricle dilatation (β = 0.512, 95% CI [0.174, 0.850]) compared to no binge drinking. Discussion: These observed associations are consistent with previous findings. Identifying how binge drinking may contribute to VBI in older AIs may suggest modifiable health behaviors for neurological risk reduction and disease prevention.
AB - Objectives: American Indians (AIs) generally consume less alcohol than the US general population; however, the prevalence of alcohol use disorder is higher. This is the first large cohort study to examine binge drinking as a risk factor for vascular brain injury (VBI). Methods: We used linear and Poisson regression to examine the association of self-reported binge drinking with VBI, measured via magnetic resonance imaging (MRI), in 817 older AIs who participated in the Strong Heart and Cerebrovascular Disease and Its Consequences in American Indians studies. Results: Any binge drinking at multiple time-points was associated with increased sulcal (β = 0.360, 95% CI [0.079, 0.641]) and ventricle dilatation (β = 0.512, 95% CI [0.174, 0.850]) compared to no binge drinking. Discussion: These observed associations are consistent with previous findings. Identifying how binge drinking may contribute to VBI in older AIs may suggest modifiable health behaviors for neurological risk reduction and disease prevention.
KW - American Indian
KW - binge drinking
KW - older adults
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U2 - 10.1177/08982643211013696
DO - 10.1177/08982643211013696
M3 - Article
C2 - 34167344
AN - SCOPUS:85108611657
SN - 0898-2643
VL - 33
SP - 51S-59S
JO - Journal of aging and health
JF - Journal of aging and health
IS - 7-8_suppl
ER -
