TY - JOUR
T1 - Associations of Growth and Body Composition with Brain Size in Preterm Infants
AU - Bell, Katherine A.
AU - Matthews, Lillian G.
AU - Cherkerzian, Sara
AU - Palmer, Caroline
AU - Drouin, Kaitlin
AU - Pepin, Hunter L.
AU - Ellard, Deirdre
AU - Inder, Terrie E.
AU - Ramel, Sara E.
AU - Belfort, Mandy B.
N1 - Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/11
Y1 - 2019/11
N2 - Objective: To assess the association of very preterm infants' brain size at term-equivalent age with physical growth from birth to term and body composition at term. Study design: We studied 62 infants born at <33 weeks of gestation. At birth and term, we measured weight and length and calculated body mass index. At term, infants underwent air displacement plethysmography to determine body composition (fat and fat-free mass) and magnetic resonance imaging to quantify brain size (bifrontal diameter, biparietal diameter, transverse cerebellar distance). We estimated associations of physical growth (Z-score change from birth to term) and body composition with brain size, adjusting for potential confounders using generalized estimating equations. Results: The median gestational age was 29 weeks (range, 24.0-32.9 weeks). Positive gains in weight and body mass index Z-score were associated with increased brain size. Each additional 100 g of fat-free mass at term was associated with larger bifrontal diameter (0.6 mm; 95% CI, 0.2-1.0 mm), biparietal diameter (0.7 mm; 95% CI, 0.3-1.1 mm), and transverse cerebellar distance (0.3 mm; 95% CI, 0.003-0.5 mm). Associations between fat mass and brain metrics were not statistically significant. Conclusions: Weight and body mass index gain from birth to term, and lean mass—but not fat—at term, were associated with larger brain size. Factors that promote lean mass accrual among preterm infants may also promote brain growth.
AB - Objective: To assess the association of very preterm infants' brain size at term-equivalent age with physical growth from birth to term and body composition at term. Study design: We studied 62 infants born at <33 weeks of gestation. At birth and term, we measured weight and length and calculated body mass index. At term, infants underwent air displacement plethysmography to determine body composition (fat and fat-free mass) and magnetic resonance imaging to quantify brain size (bifrontal diameter, biparietal diameter, transverse cerebellar distance). We estimated associations of physical growth (Z-score change from birth to term) and body composition with brain size, adjusting for potential confounders using generalized estimating equations. Results: The median gestational age was 29 weeks (range, 24.0-32.9 weeks). Positive gains in weight and body mass index Z-score were associated with increased brain size. Each additional 100 g of fat-free mass at term was associated with larger bifrontal diameter (0.6 mm; 95% CI, 0.2-1.0 mm), biparietal diameter (0.7 mm; 95% CI, 0.3-1.1 mm), and transverse cerebellar distance (0.3 mm; 95% CI, 0.003-0.5 mm). Associations between fat mass and brain metrics were not statistically significant. Conclusions: Weight and body mass index gain from birth to term, and lean mass—but not fat—at term, were associated with larger brain size. Factors that promote lean mass accrual among preterm infants may also promote brain growth.
KW - air displacement plethysmography
KW - body composition
KW - brain metrics
KW - preterm
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U2 - 10.1016/j.jpeds.2019.06.062
DO - 10.1016/j.jpeds.2019.06.062
M3 - Article
C2 - 31377040
AN - SCOPUS:85069895307
SN - 0022-3476
VL - 214
SP - 20-26.e2
JO - Journal of Pediatrics
JF - Journal of Pediatrics
ER -