Asymptomatic Clostridium difficile colonization as a reservoir for Clostridium difficile infection

Alison L. Galdys; Scott R. Curry; Lee H. Harrison

doi:10.1586/14787210.2014.920252

Asymptomatic Clostridium difficile colonization as a reservoir for Clostridium difficile infection

Alison L. Galdys, Scott R. Curry, Lee H. Harrison

Medicine - Infectious Disease and International

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

Clostridium difficile (CD) infection (CDI) is the leading cause of healthcare associated diarrhea despite intense hospital infection prevention programs. A substantial proportion of the population is asymptomatically colonized with CD, and evidence is mounting that these individuals serve as a reservoir for CDI. The purpose of this review is to discuss the mechanisms by which individuals may harbor toxigenic CD but remain asymptomatic, the evidence that asymptomatically colonized individuals serve as a source of CDI, and the implications of this potential CD reservoir for healthcare infection prevention.

Original language	English (US)
Pages (from-to)	967-980
Number of pages	14
Journal	Expert Review of Anti-Infective Therapy
Volume	12
Issue number	8
DOIs	https://doi.org/10.1586/14787210.2014.920252
State	Published - Aug 2014

Keywords

Clostridium difficile
Clostridium difficile infection
asymptomatic carriage
colonization
epidemiology
molecular epidemiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Clostridium difficile (CD) infection (CDI) is the leading cause of healthcare associated diarrhea despite intense hospital infection prevention programs. A substantial proportion of the population is asymptomatically colonized with CD, and evidence is mounting that these individuals serve as a reservoir for CDI. The purpose of this review is to discuss the mechanisms by which individuals may harbor toxigenic CD but remain asymptomatic, the evidence that asymptomatically colonized individuals serve as a source of CDI, and the implications of this potential CD reservoir for healthcare infection prevention.",

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AB - Clostridium difficile (CD) infection (CDI) is the leading cause of healthcare associated diarrhea despite intense hospital infection prevention programs. A substantial proportion of the population is asymptomatically colonized with CD, and evidence is mounting that these individuals serve as a reservoir for CDI. The purpose of this review is to discuss the mechanisms by which individuals may harbor toxigenic CD but remain asymptomatic, the evidence that asymptomatically colonized individuals serve as a source of CDI, and the implications of this potential CD reservoir for healthcare infection prevention.

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KW - asymptomatic carriage

KW - colonization

KW - epidemiology

KW - molecular epidemiology

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Asymptomatic Clostridium difficile colonization as a reservoir for Clostridium difficile infection

Abstract

Keywords

UN SDGs

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