TY - JOUR
T1 - Atopic disease and immunoglobulin E in twins reared apart and together
AU - Hanson, Bruce
AU - McGue, Matthew
AU - Roitman-Johnson, Beatrice
AU - Segal, Nancy L.
AU - Bouchard, Thomas J.
AU - Blumenthal, M. N.
PY - 1991/5
Y1 - 1991/5
N2 - Both genetic and environmental influences have been implicated in the etiology of atopic disease and in the determination of serum IgE levels. To quantify the relative contribution of these influences, we studied the prevalence of asthma and seasonal rhinitis, skin-test response, total serum IgE levels, and specific IgE, as measured by RAST, in a sample of MZ and DZ twins reared apart or together. Concordance rates for asthma, rhinitis, positive skin tests, and RAST were calculated. MZ twins, whether reared apart or together, showed a greater concordance than dizygotic twins reared apart or together. Maximum-likelihood tests of genetic and environmental components of the variation of total IgE levels revealed a substantial genetic component and a negligible contribution from common familial environmental effects.
AB - Both genetic and environmental influences have been implicated in the etiology of atopic disease and in the determination of serum IgE levels. To quantify the relative contribution of these influences, we studied the prevalence of asthma and seasonal rhinitis, skin-test response, total serum IgE levels, and specific IgE, as measured by RAST, in a sample of MZ and DZ twins reared apart or together. Concordance rates for asthma, rhinitis, positive skin tests, and RAST were calculated. MZ twins, whether reared apart or together, showed a greater concordance than dizygotic twins reared apart or together. Maximum-likelihood tests of genetic and environmental components of the variation of total IgE levels revealed a substantial genetic component and a negligible contribution from common familial environmental effects.
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M3 - Article
C2 - 2018039
AN - SCOPUS:0025882116
SN - 0002-9297
VL - 48
SP - 873
EP - 879
JO - American Journal of Human Genetics
JF - American Journal of Human Genetics
IS - 5
ER -